Seroatlas · Human Serome Atlas

SAMD5

Sterile alpha motif domain-containing protein 5

Also known as: dJ875H10.1, SAMD5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5TGI4
Gene
SAMD5
Ensembl
ENSG00000203727
Chromosome
6
Canonical length
173 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Predicted to be involved in regulation of intracellular signal transduction. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

173 residues, UniProt reviewed canonical sequence.

>Q5TGI4|SAMD5
     1  MCTNIVYEWL KALQLPQYAE SFVDNGYDDL EVCKQIGDPD LDAIGVLAPA HRRRILEAVR
    61  RLREQDANAA GLYFTLEPQP APPGPPADAV PTGRRGEPCG GPAQGTRGDS RGHTTAPRSR
   121  ELVSYPKLKL KIMIRDKLVR DGIHLSKPPY SRKVPMAGIL EYLMNWPKSS QSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAMD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 11 nTPM
  • esophagus: 8.2 nTPM
  • retina: 8.2 nTPM
  • rectum: 7.5 nTPM
  • testis: 7.1 nTPM
  • kidney: 6.9 nTPM

Single-cell type

  • retinal bipolar cells: 911 nCPM
  • sertoli cells: 644 nCPM
  • distal convoluted tubule cells: 557 nCPM
  • pituicytes/fscs: 485 nCPM
  • lactotrophs: 462 nCPM
  • proximal tubule cells: 432 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • pons: 24 nTPM
  • thalamus: 21 nTPM
  • basal ganglia: 17 nTPM
  • medulla oblongata: 15 nTPM
  • midbrain: 14 nTPM
  • hypothalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.7
gnomAD pLI
0.01
gnomAD missense Z
0.42
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAMD5 as an antibody target. Whether an autoantibody or antibody against SAMD5 could matter depends on whether native SAMD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAMD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAMD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SAMD5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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