Seroatlas · Human Serome Atlas

SAMD3

Sterile alpha motif domain-containing protein 3

Also known as: bA73O6.2, FLJ34032, SAMD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6K7
Gene: SAMD3
Ensembl: ENSG00000164483
Chromosome: 6
Canonical length: 520 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for SAMD3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q8N6K7|SAMD3
     1  METWSVEQVC SWLVEKNLGE LVHRFQEEEV SGAALLALND RMVQQLVKKI GHQAVLMDLI
    61  KKYKQNTQGL KSPENPKKAA LVMQTEAARD YRDEESSSPA RHGEQMPSFY PAENLDNGLI
   121  DQRVLKQRRN VKQILARSKA LQWTKSYVLP EFPYDVKCML AEQKCPDHSM RIRIIEFLQA
   181  DMTKYLEGSL YPSTQQYNDV VNALLQAHPF LDEDGCGFFL WKRALKDRFK YVRRPIEDDE
   241  QVIRNKCKFG HRRGQTRKSL ADIRFDEIKL VQIKEEAVCF DSELDEHIKW FQQEYVKTEK
   301  DWREIDKRMS QTLEIRRKMI GSRTPLKDIL KLFPFLKCPY QMFREFQLLT RTDIYKKTRH
   361  ILESYSENIL TSFSVVDNPI NIVLQEKMKH YTDEDMLKYM KMTATCLLLP DVFGDDPSLF
   421  VIMNEQVQVS TPVLEVKNPF NMEVCEFSLY LERERLTKVD DCVTALAALV AAFHVFRIEC
   481  PRRLSQTFNF LETLIFDMHS PYFPSLKEKE NEVGFQHPLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAMD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 9.7 nTPM

Expression across tissuesHPA

Tissue

lymph node: 9.7 nTPM
spleen: 8.7 nTPM
thymus: 5.8 nTPM
pituitary gland: 4.5 nTPM
endometrium: 4.1 nTPM
bone marrow: 4 nTPM

Single-cell type

nk-cells: 534 nCPM
t-cells: 234 nCPM
pancreatic islet cells: 228 nCPM
neuroendocrine cells: 221 nCPM
retinal ganglion cells: 220 nCPM
gonadotrophs: 190 nCPM

Immune cell

NK-cell: 129 nTPM
gdT-cell: 114 nTPM
memory CD8 T-cell: 102 nTPM
MAIT T-cell: 90 nTPM
naive CD8 T-cell: 69 nTPM
T-reg: 42 nTPM

Brain region

hippocampal formation: 6.5 nTPM
midbrain: 5.1 nTPM
cerebral cortex: 4.7 nTPM
hypothalamus: 4.5 nTPM
amygdala: 3.5 nTPM
pons: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Sterile alpha motif domain
Sterile alpha motif/pointed domain superfamily
SAM domain (Sterile alpha motif)
Sterile alpha motif domain-containing protein 3
SAMD3, SAM domain

InteractionsUniProt · HPA

Protein binding partners of SAMD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KDM1A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAMD3 as an antibody target. Whether an autoantibody or antibody against SAMD3 could matter depends on whether native SAMD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAMD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAMD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...