Seroatlas · Human Serome Atlas

SAMD15

Sterile alpha motif domain-containing protein 15

Also known as: C14orf174, FAM15A, FLJ35963, SAM15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P1V8
Gene: SAMD15
Ensembl: ENSG00000100583
Chromosome: 14
Canonical length: 674 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

674 residues, UniProt reviewed canonical sequence.

>Q9P1V8|SAMD15
     1  MAEVPEDYDS GPDEDGELEP ERPELPGLHK LYENAEPDTM AKADSKLPAE IYQEPQPETE
    61  EEDFKEGEPD SAKNVQLKPG GTSQEGIAKE SKRDVPSETE PGIHQEVKSE TSREMGEFFK
   121  DLEAPMDETH KESDLEPPEE AKPNVTEDVF LESAMETDPD PVPPTETMSE VSGATVRERN
   181  LELLEEETEP GVPEESLRVQ HEETGLEPPE QTKQDFPSEK LGESLEETDL QPPKMTKPET
   241  PEETQRESTE KKRTEPPEQA RLEFLEKEPR KSSEEAGLEP PEETQPEVPE EMQRKATEEK
   301  GTELPERTKP DFPDHKPRKS TDENVPEPLE EIKLEFPEEE SRKTNEETIL EQSEMMKPES
   361  PEEIRKSNEK KNPQPPEETG PVLPQEINPQ VEEKTQTKPT EKILELPDET KPRETHVEFS
   421  KEDRPEPIKS KYSVGNDELE HREPKRGKLS LSDKFRKEYY ALGSLRESEE SIGTHYEFLQ
   481  PLQKLLNVSE ECSYSDPSES QTELSEFVHE KEVVDLSQEL KERVSEDDET QPEKGTELQF
   541  EHLNWDPEEV AEWISQLGFP QYKECFITNF ISGRKLIHVN CSNLPQMGIT NFEDMKAISR
   601  HTQELLEIEE PLFKRSISLP YRDIIGLYLE QKGHTGIKSD SLTLSEFVKA AGLQDYAPEI
   661  TAPEENEELP CTEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAMD15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
retina: 14 nTPM
epididymis: 5 nTPM
fallopian tube: 4 nTPM
thyroid gland: 3.5 nTPM
choroid plexus: 2.9 nTPM

Single-cell type

late spermatids: 190 nCPM
late primary spermatocytes: 130 nCPM
respiratory ciliated cells: 85 nCPM
early spermatids: 73 nCPM
cone photoreceptor cells: 56 nCPM
fallopian tube ciliated cells: 56 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.5 nTPM
eosinophil: 0.2 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
non-classical monocyte: 0.1 nTPM

Brain region

choroid plexus: 22 nTPM
midbrain: 14 nTPM
hypothalamus: 13 nTPM
medulla oblongata: 13 nTPM
basal ganglia: 12 nTPM
thalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

protein serine/threonine kinase activator activity

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAMD15 as an antibody target. Whether an autoantibody or antibody against SAMD15 could matter depends on whether native SAMD15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAMD15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAMD15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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