Seroatlas · Human Serome Atlas

SAMD14

Sterile alpha motif domain-containing protein 14

Also known as: FLJ36890, SAM14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZD0
Gene: SAMD14
Ensembl: ENSG00000167100
Chromosome: 17
Canonical length: 417 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization; calcium-mediated signaling; and neuron projection development. Predicted to be active in several cellular components, including actin cytoskeleton; dendrite; and postsynaptic density. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>Q8IZD0|SAMD14
     1  MASSKLREPV DEVFDLDLAV PETARLDSSL HKARAQLLAK GRRHRPSRSR LRDSASSAED
    61  GEGSDGPGGK VTDGCGSPLH RLRSPLHSGP GSPAGGSFCL DPPGLRRSLD EDEPPPSPLT
   121  RYRPLHNAAS HEGLAAASCS PPRSAPSSDS SPSFVRRHPR AEPHSEDDSR DASPPEPASP
   181  TIGLDKKTRR KFLDLGVTLR RASTGKSRKE KGSNRLSMGS RESVEGSGRS GGSPFLPFSW
   241  FTDSGKGSAS SGSTTSPTCS PKHEGFSPKK SASQESTLSD DSTPPSSSPK IPSGPWQEAK
   301  CSYPYHTLSQ SSDEFLDEPL PPVHHWTSQQ VGQWLQSLNL EQYAAEFAAR QVDGPQLLQL
   361  DGSKLKSLGL SNSHDRALVK RKLKEMAAAA EKERKAQEKA ARQREKLRRR EQEAKKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAMD14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 67 nTPM
cerebral cortex: 36 nTPM
amygdala: 34 nTPM
basal ganglia: 33 nTPM
hippocampal formation: 31 nTPM
hypothalamus: 17 nTPM

Single-cell type

megakaryocytes: 235 nCPM
platelets: 73 nCPM
retinal bipolar cells: 61 nCPM
epididymal principal cells: 41 nCPM
cardiomyocytes: 37 nCPM
retinal amacrine cells: 33 nCPM

Immune cell

basophil: 0.6 nTPM
eosinophil: 0.2 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 50 nTPM
hippocampal formation: 41 nTPM
cerebral cortex: 41 nTPM
amygdala: 40 nTPM
basal ganglia: 39 nTPM
hypothalamus: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
gnomAD missense Z: 1.13
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

actin filament binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAMD14 as an antibody target. Whether an autoantibody or antibody against SAMD14 could matter depends on whether native SAMD14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAMD14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAMD14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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