Seroatlas · Human Serome Atlas

SAMD11

Sterile alpha motif domain-containing protein 11

Also known as: MGC45873, SAM11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NU1
Gene: SAMD11
Ensembl: ENSG00000187634
Chromosome: 1
Canonical length: 681 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and retinal rod cell development. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be part of PRC1 complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

681 residues, UniProt reviewed canonical sequence.

>Q96NU1|SAMD11
     1  MSKGILQVHP PICDCPGCRI SSPVNRGRLA DKRTVALPAA RNLKKERTPS FSASDGDSDG
    61  SGPTCGRRPG LKQEDGPHIR IMKRRVHTHW DVNISFREAS CSQDGNLPTL ISSVHRSRHL
   121  VMPEHQSRCE FQRGSLEIGL RPAGDLLGKR LGRSPRISSD CFSEKRARSE SPQEALLLPR
   181  ELGPSMAPED HYRRLVSALS EASTFEDPQR LYHLGLPSHG EDPPWHDPPH HLPSHDLLRV
   241  RQEVAAAALR GPSGLEAHLP SSTAGQRRKQ GLAQHREGAA PAAAPSFSER ELPQPPPLLS
   301  PQNAPHVALG PHLRPPFLGV PSALCQTPGY GFLPPAQAEM FAWQQELLRK QNLARLELPA
   361  DLLRQKELES ARPQLLAPET ALRPNDGAEE LQRRGALLVL NHGAAPLLAL PPQGPPGSGP
   421  PTPSRDSARR APRKGGPGPA SARPSESKEM TGARLWAQDG SEDEPPKDSD GEDPETAAVG
   481  CRGPTPGQAP AGGAGAEGKG LFPGSTLPLG FPYAVSPYFH TGAVGGLSMD GEEAPAPEDV
   541  TKWTVDDVCS FVGGLSGCGE YTRVFREQGI DGETLPLLTE EHLLTNMGLK LGPALKIRAQ
   601  VARRLGRVFY VASFPVALPL QPPTLRAPER ELGTGEQPLS PTTATSPYGG GHALAGQTSP
   661  KQENGTLALL PGAPDPSQPL C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAMD11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 35 nTPM
fallopian tube: 24 nTPM
retina: 23 nTPM
prostate: 21 nTPM
spleen: 19 nTPM
seminal vesicle: 18 nTPM

Single-cell type

rod photoreceptor cells: 153 nCPM
pancreatic islet cells: 72 nCPM
adrenal medulla cells: 64 nCPM
somatotrophs: 63 nCPM
thymic myoid cells: 52 nCPM
smooth muscle cells: 47 nCPM

Immune cell

NK-cell: 1.3 nTPM
MAIT T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

medulla oblongata: 51 nTPM
cerebral cortex: 26 nTPM
midbrain: 24 nTPM
white matter: 21 nTPM
hypothalamus: 21 nTPM
thalamus: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SAMD11.

Disease | AllUniProt

Conditions SAMD11 is implicated in, by any mechanism.

Retinitis pigmentosa (RP) MIM:268000

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: -3.44
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAMD11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAMD11 as an antibody target. Whether an autoantibody or antibody against SAMD11 could matter depends on whether native SAMD11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAMD11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAMD11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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