Seroatlas · Human Serome Atlas

SAMD10

Sterile alpha motif domain-containing protein 10

Also known as: C20orf136, SAM10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYL1
Gene: SAMD10
Ensembl: ENSG00000130590
Chromosome: 20
Canonical length: 202 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasmic side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>Q9BYL1|SAMD10
     1  MFTELRSKLS PPRGRAGAVR AGFGERRDVD ATAHFSFCRT LLEHTVSAES IPCHLPRTPG
    61  TSLTWHDSRS QRAASSRPIK LLQQPGTDTP QGRLYSDHYG LYHTSPSLGG LTRPVVLWSQ
   121  QDVCKWLKKH CPHNYLVYVE AFSQHAITGR ALLRLNAEKL QRMGLAQEAQ RQEVLQQVLR
   181  LQVREEGRSL QLLSQASFGK MS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAMD10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 30 nTPM
basal ganglia: 17 nTPM
esophagus: 13 nTPM
cerebral cortex: 8.8 nTPM
kidney: 8.1 nTPM
amygdala: 7.4 nTPM

Single-cell type

esophageal apical cells: 51 nCPM
esophageal suprabasal cells: 18 nCPM
breast lactating cells: 13 nCPM
brain inhibitory neurons: 12 nCPM
adrenal medulla cells: 11 nCPM
parietal cells: 11 nCPM

Immune cell

naive CD8 T-cell: 3.5 nTPM
naive CD4 T-cell: 3.1 nTPM
gdT-cell: 2.7 nTPM
memory CD4 T-cell: 1.7 nTPM
memory B-cell: 1.6 nTPM
memory CD8 T-cell: 1.6 nTPM

Brain region

cerebellum: 22 nTPM
basal ganglia: 17 nTPM
cerebral cortex: 14 nTPM
amygdala: 12 nTPM
thalamus: 11 nTPM
hippocampal formation: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.79
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell surface receptor protein tyrosine kinase signaling pathway

Cellular components

cytoplasmic side of plasma membrane

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAMD10 as an antibody target. Whether an autoantibody or antibody against SAMD10 could matter depends on whether native SAMD10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAMD10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAMD10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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