Seroatlas · Human Serome Atlas

SAMD1

Sterile alpha motif domain-containing protein 1

Also known as: SAMD1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6SPF0
Gene: SAMD1
Canonical length: 538 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homopolymer

OverviewNCBI Gene

No narrative summary is available for SAMD1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

538 residues, UniProt reviewed canonical sequence.

>Q6SPF0|SAMD1
     1  MAGPPALPPP ETAAAATTAA AASSSAASPH YQEWILDTID SLRSRKARPD LERICRMVRR
    61  RHGPEPERTR AELEKLIQQR AVLRVSYKGS ISYRNAARVQ PPRRGATPPA PPRAPRGAPA
   121  AAAAAAPPPT PAPPPPPAPV AAAAPARAPR AAAAAATAPP SPGPAQPGPR AQRAAPLAAP
   181  PPAPAAPPAV APPAGPRRAP PPAVAAREPP LPPPPQPPAP PQQQQPPPPQ PQPPPEGGAV
   241  RAGGAARPVS LREVVRYLGG SGGAGGRLTR GRVQGLLEEE AAARGRLERT RLGALALPRG
   301  DRPGRAPPAA SARPSRSKRG GEERVLEKEE EEDDDEDEDE EDDVSEGSEV PESDRPAGAQ
   361  HHQLNGERGP QSAKERVKEW TPCGPHQGQD EGRGPAPGSG TRQVFSMAAM NKEGGTASVA
   421  TGPDSPSPVP LPPGKPALPG ADGTPFGCPP GRKEKPSDPV EWTVMDVVEY FTEAGFPEQA
   481  TAFQEQEIDG KSLLLMQRTD VLTGLSIRLG PALKIYEHHI KVLQQGHFED DDPDGFLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAMD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 49 nTPM
amygdala: 48 nTPM
spinal cord: 47 nTPM
midbrain: 45 nTPM
hippocampal formation: 44 nTPM
thymus: 41 nTPM

Single-cell type

astrocytes: 13 nCPM
bergmann glia: 12 nCPM
microglia: 12 nCPM
ependymal cells: 12 nCPM
oligodendrocyte progenitor cells: 11 nCPM
papillary tip epithelial cells: 11 nCPM

Immune cell

NK-cell: 3.8 nTPM
eosinophil: 2.5 nTPM
memory B-cell: 2.1 nTPM
naive B-cell: 1.4 nTPM
classical monocyte: 1.3 nTPM
myeloid DC: 1.2 nTPM

Brain region

medulla oblongata: 69 nTPM
white matter: 61 nTPM
amygdala: 61 nTPM
thalamus: 60 nTPM
spinal cord: 59 nTPM
pons: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.24
gnomAD missense Z: 0.06

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Sterile alpha motif domain
Sterile alpha motif/pointed domain superfamily
SAM domain-containing protein 1-like, WH domain
SAM domain (Sterile alpha motif)
SAM domain-containing protein 1, WH domain
SAMD1-like, small helical domain
SAMD1 small helical domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAMD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KDM1A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAMD1 as an antibody target. Whether an autoantibody or antibody against SAMD1 could matter depends on whether native SAMD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAMD1 is annotated as secreted, so native SAMD1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SAMD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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