Seroatlas · Human Serome Atlas

SAC3D1

SAC3 domain-containing protein 1

Also known as: SAC31_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NKF1
Gene: SAC3D1
Canonical length: 404 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for SAC3D1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

404 residues, UniProt reviewed canonical sequence.

>A6NKF1|SAC3D1
     1  MAGRRAQTGS APPRPAAPHP RPASRAFPQH CRPRDAERPP SPRSPLMPGC ELPVGTCPDM
    61  CPAAERAQRE REHRLHRLEV VPGCRQDPPR ADPQRAVKEY SRPAAGKPRP PPSQLRPPSV
   121  LLATVRYLAG EVAESADIAR AEVASFVADR LRAVLLDLAL QGAGDAEAAV VLEAALATLL
   181  TVVARLGPDA ARGPADPVLL QAQVQEGFGS LRRCYARGAG PHPRQPAFQG LFLLYNLGSV
   241  EALHEVLQLP AALRACPPLR KALAVDAAFR EGNAARLFRL LQTLPYLPSC AVQCHVGHAR
   301  REALARFARA FSTPKGQTLP LGFMVNLLAL DGLREARDLC QAHGLPLDGE ERVVFLRGRY
   361  VEEGLPPAST CKVLVESKLR GRTLEEVVMA EEEDEGTDRP GSPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAC3D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

testis: 44 nTPM
cerebellum: 14 nTPM
skeletal muscle: 11 nTPM
liver: 10 nTPM
cerebral cortex: 9.9 nTPM
basal ganglia: 9.3 nTPM

Single-cell type

late primary spermatocytes: 234 nCPM
late spermatids: 180 nCPM
early primary spermatocytes: 102 nCPM
early spermatids: 83 nCPM
esophageal basal cells: 67 nCPM
extravillous trophoblasts: 48 nCPM

Immune cell

plasmacytoid DC: 1.6 nTPM
non-classical monocyte: 1.5 nTPM
classical monocyte: 1.4 nTPM
intermediate monocyte: 1.1 nTPM
naive B-cell: 1.1 nTPM
naive CD4 T-cell: 1.1 nTPM

Brain region

medulla oblongata: 14 nTPM
pons: 12 nTPM
thalamus: 12 nTPM
cerebral cortex: 11 nTPM
midbrain: 11 nTPM
white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
gnomAD missense Z: 0.6
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAC3D1 as an antibody target. Whether an autoantibody or antibody against SAC3D1 could matter depends on whether native SAC3D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAC3D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAC3D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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