Seroatlas · Human Serome Atlas

S1PR5

Sphingosine 1-phosphate receptor 5

Also known as: Edg-8, EDG8, S1PR5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H228
Gene
S1PR5
Ensembl
ENSG00000180739
Chromosome
19
Canonical length
398 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>Q9H228|S1PR5
     1  MESGLLRPAP VSEVIVLHYN YTGKLRGARY QPGAGLRADA VVCLAVCAFI VLENLAVLLV
    61  LGRHPRFHAP MFLLLGSLTL SDLLAGAAYA ANILLSGPLT LKLSPALWFA REGGVFVALT
   121  ASVLSLLAIA LERSLTMARR GPAPVSSRGR TLAMAAAAWG VSLLLGLLPA LGWNCLGRLD
   181  ACSTVLPLYA KAYVLFCVLA FVGILAAICA LYARIYCQVR ANARRLPARP GTAGTTSTRA
   241  RRKPRSLALL RTLSVVLLAF VACWGPLFLL LLLDVACPAR TCPVLLQADP FLGLAMANSL
   301  LNPIIYTLTN RDLRHALLRL VCCGRHSCGR DPSGSQQSAS AAEASGGLRR CLPPGLDGSF
   361  SGSERSSPQR DGLDTSGSTG SPGAPTAART LVSEPAAD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S1PR5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 48 nTPM
  • midbrain: 35 nTPM
  • hippocampal formation: 25 nTPM
  • basal ganglia: 21 nTPM
  • amygdala: 16 nTPM
  • bone marrow: 15 nTPM

Single-cell type

  • nk-cells: 82 nCPM
  • oligodendrocytes: 25 nCPM
  • esophageal basal cells: 23 nCPM
  • submucosal glandular cells: 12 nCPM
  • basal prostatic cells: 12 nCPM
  • prostatic hillock cells: 11 nCPM

Immune cell

  • gdT-cell: 300 nTPM
  • MAIT T-cell: 185 nTPM
  • memory CD8 T-cell: 145 nTPM
  • naive CD8 T-cell: 109 nTPM
  • total PBMC: 64 nTPM
  • NK-cell: 44 nTPM

Brain region

  • white matter: 108 nTPM
  • medulla oblongata: 68 nTPM
  • basal ganglia: 59 nTPM
  • midbrain: 56 nTPM
  • pons: 53 nTPM
  • cerebellum: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0.16
gnomAD missense Z
1.45
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads S1PR5 as an antibody target. Whether an autoantibody or antibody against S1PR5 could matter depends on whether native S1PR5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

S1PR5 is annotated at the cell surface, where native S1PR5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label S1PR5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/S1PR5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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