Seroatlas · Human Serome Atlas

S1PR3

Sphingosine 1-phosphate receptor 3

Also known as: bA791O21.3, C9orf108, C9orf47, EDG-3, EDG3, FLJ37523, S1PR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99500
Gene: S1PR3
Ensembl: ENSG00000213694
Chromosome: 9
Canonical length: 378 aa
Protein class: FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

378 residues, UniProt reviewed canonical sequence.

>Q99500|S1PR3
     1  MATALPPRLQ PVRGNETLRE HYQYVGKLAG RLKEASEGST LTTVLFLVIC SFIVLENLMV
    61  LIAIWKNNKF HNRMYFFIGN LALCDLLAGI AYKVNILMSG KKTFSLSPTV WFLREGSMFV
   121  ALGASTCSLL AIAIERHLTM IKMRPYDANK RHRVFLLIGM CWLIAFTLGA LPILGWNCLH
   181  NLPDCSTILP LYSKKYIAFC ISIFTAILVT IVILYARIYF LVKSSSRKVA NHNNSERSMA
   241  LLRTVVIVVS VFIACWSPLF ILFLIDVACR VQACPILFKA QWFIVLAVLN SAMNPVIYTL
   301  ASKEMRRAFF RLVCNCLVRG RGARASPIQP ALDPSRSKSS SSNNSSHSPK VKEDLPHTAP
   361  SSCIMDKNAA LQNGIFCN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S1PR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 59 nTPM
smooth muscle: 34 nTPM
kidney: 26 nTPM
fallopian tube: 25 nTPM
cervix: 25 nTPM
adrenal gland: 24 nTPM

Single-cell type

vascular smooth muscle cells: 64 nCPM
endometrial stromal cells: 60 nCPM
pericytes: 53 nCPM
smooth muscle cells: 45 nCPM
fibroblasts: 38 nCPM
decidual stromal cells: 33 nCPM

Immune cell

classical monocyte: 7 nTPM
total PBMC: 2.1 nTPM
basophil: 0.3 nTPM
intermediate monocyte: 0.3 nTPM
neutrophil: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

medulla oblongata: 31 nTPM
thalamus: 24 nTPM
white matter: 24 nTPM
hypothalamus: 21 nTPM
choroid plexus: 19 nTPM
midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0.05
gnomAD missense Z: 0.85
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
Sphingosine 1-phosphate receptor
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
EDG-3 sphingosine 1-phosphate receptor

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads S1PR3 as an antibody target. Whether an autoantibody or antibody against S1PR3 could matter depends on whether native S1PR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

S1PR3 is annotated at the cell surface, where native S1PR3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label S1PR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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