Seroatlas · Human Serome Atlas

S1PR2

Sphingosine 1-phosphate receptor 2

Also known as: AGR16, DFNB68, EDG5, Gpcr13, H218, S1PR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95136
Gene
S1PR2
Ensembl
ENSG00000267534
Chromosome
19
Canonical length
353 aa
Protein class
Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins
Subcellular location
Nuclear speckles,Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

353 residues, UniProt reviewed canonical sequence.

>O95136|S1PR2
     1  MGSLYSEYLN PNKVQEHYNY TKETLETQET TSRQVASAFI VILCCAIVVE NLLVLIAVAR
    61  NSKFHSAMYL FLGNLAASDL LAGVAFVANT LLSGSVTLRL TPVQWFAREG SAFITLSASV
   121  FSLLAIAIER HVAIAKVKLY GSDKSCRMLL LIGASWLISL VLGGLPILGW NCLGHLEACS
   181  TVLPLYAKHY VLCVVTIFSI ILLAIVALYV RIYCVVRSSH ADMAAPQTLA LLKTVTIVLG
   241  VFIVCWLPAF SILLLDYACP VHSCPILYKA HYFFAVSTLN SLLNPVIYTW RSRDLRREVL
   301  RPLQCWRPGV GVQGRRRGGT PGHHLLPLRS SSSLERGMHM PTSPTFLEGN TVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S1PR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 17 nTPM
  • lung: 13 nTPM
  • testis: 13 nTPM
  • cervix: 10 nTPM
  • lymph node: 10 nTPM
  • tonsil: 10 nTPM

Single-cell type

  • late spermatids: 112 nCPM
  • early spermatids: 19 nCPM
  • late primary spermatocytes: 1.4 nCPM
  • thymocytes: 0.8 nCPM
  • endometrial stromal cells: 0.7 nCPM
  • salivary myoepithelial cells: 0.6 nCPM

Immune cell

  • basophil: 45 nTPM
  • T-reg: 12 nTPM
  • memory CD4 T-cell: 9.2 nTPM
  • MAIT T-cell: 8.8 nTPM
  • gdT-cell: 7.2 nTPM
  • memory CD8 T-cell: 6.9 nTPM

Brain region

  • medulla oblongata: 6.8 nTPM
  • white matter: 6.8 nTPM
  • pons: 5.5 nTPM
  • thalamus: 5.5 nTPM
  • hypothalamus: 5.3 nTPM
  • cerebral cortex: 5.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about S1PR2.

Disease | AllUniProt

Conditions S1PR2 is implicated in, by any mechanism.

  • Deafness, autosomal recessive, 68 (DFNB68) MIM:610419

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 144 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Autosomal recessive nonsyndromic hearing loss 68

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.05
gnomAD pLI
0.02
gnomAD missense Z
1.53
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads S1PR2 as an antibody target. Whether an autoantibody or antibody against S1PR2 could matter depends on whether native S1PR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

S1PR2 is annotated at the cell surface, where native S1PR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label S1PR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/S1PR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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