S100A7L2
Protein S100-A7-like 2
Also known as: S1A7B_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for S100A7L2 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
101 residues, UniProt reviewed canonical sequence.
>Q5SY68|S100A7L2
1 MNIPLGEKVM LDIVAMFRQY SGDDGRMDMP GLVNLMKENF PNFLSGCEKS DMDYLSNALE
61 KKDDNKDKKV NYSEFLSLLG DITIDHHKIM HGVAPCSGGS QLocalizationUniProt · AlphaFold · HPA
Whether an antibody against S100A7L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.58
- gnomAD pLI
- 0.19
- gnomAD missense Z
- -0.39
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads S100A7L2 as an antibody target. Whether an autoantibody or antibody against S100A7L2 could matter depends on whether native S100A7L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
S100A7L2 is annotated as secreted, so native S100A7L2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label S100A7L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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