Seroatlas · Human Serome Atlas

RXFP4

Relaxin-3 receptor 2

Also known as: GPCR142, GPR100, RL3R2_HUMAN, RLN3R2, RXFPR4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TDU9
Gene: RXFP4
Ensembl: ENSG00000173080
Chromosome: 1
Canonical length: 374 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>Q8TDU9|RXFP4
     1  MPTLNTSASP PTFFWANASG GSVLSADDAP MPVKFLALRL MVALAYGLVG AIGLLGNLAV
    61  LWVLSNCARR APGPPSDTFV FNLALADLGL ALTLPFWAAE SALDFHWPFG GALCKMVLTA
   121  TVLNVYASIF LITALSVARY WVVAMAAGPG THLSLFWARI ATLAVWAAAA LVTVPTAVFG
   181  VEGEVCGVRL CLLRFPSRYW LGAYQLQRVV LAFMVPLGVI TTSYLLLLAF LQRRQRRRQD
   241  SRVVARSVRI LVASFFLCWF PNHVVTLWGV LVKFDLVPWN STFYTIQTYV FPVTTCLAHS
   301  NSCLNPVLYC LLRREPRQAL AGTFRDLRLR LWPQGGGWVQ QVALKQVGRR WVASNPRESR
   361  PSTLLTNLDR GTPG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RXFP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 1.8 nTPM

Expression across tissuesHPA

Tissue

colon: 1.8 nTPM
rectum: 1.7 nTPM
duodenum: 1.3 nTPM
small intestine: 0.8 nTPM
bone marrow: 0.6 nTPM
appendix: 0.2 nTPM

Single-cell type

neuroendocrine cells: 51 nCPM
enteric stem cells: 5 nCPM
colonocytes: 3.8 nCPM
enteric transient amplifying cells: 3.8 nCPM
goblet cells: 2.8 nCPM
gastric progenitor cells: 1.3 nCPM

Immune cell

eosinophil: 0.2 nTPM
intermediate monocyte: 0.2 nTPM
non-classical monocyte: 0.2 nTPM
classical monocyte: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM

Brain region

cerebellum: 4.8 nTPM
basal ganglia: 1.5 nTPM
cerebral cortex: 1.5 nTPM
pons: 1.3 nTPM
white matter: 1.1 nTPM
medulla oblongata: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: 0.66
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

galanin receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RXFP4 as an antibody target. Whether an autoantibody or antibody against RXFP4 could matter depends on whether native RXFP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RXFP4 is annotated at the cell surface, where native RXFP4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RXFP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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