Seroatlas · Human Serome Atlas

RXFP3

Relaxin-3 receptor 1

Also known as: GPCR135, RL3R1_HUMAN, RLN3R1, RXFPR3, SALPR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NSD7
Gene: RXFP3
Ensembl: ENSG00000182631
Chromosome: 5
Canonical length: 469 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable G protein-coupled peptide receptor activity. Involved in positive regulation of cytokinesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>Q9NSD7|RXFP3
     1  MQMADAATIA TMNKAAGGDK LAELFSLVPD LLEAANTSGN ASLQLPDLWW ELGLELPDGA
    61  PPGHPPGSGG AESADTEARV RILISVVYWV VCALGLAGNL LVLYLMKSMQ GWRKSSINLF
   121  VTNLALTDFQ FVLTLPFWAV ENALDFKWPF GKAMCKIVSM VTSMNMYASV FFLTAMSVTR
   181  YHSVASALKS HRTRGHGRGD CCGRSLGDSC CFSAKALCVW IWALAALASL PSAIFSTTVK
   241  VMGEELCLVR FPDKLLGRDR QFWLGLYHSQ KVLLGFVLPL GIIILCYLLL VRFIADRRAA
   301  GTKGGAAVAG GRPTGASARR LSKVTKSVTI VVLSFFLCWL PNQALTTWSI LIKFNAVPFS
   361  QEYFLCQVYA FPVSVCLAHS NSCLNPVLYC LVRREFRKAL KSLLWRIASP SITSMRPFTA
   421  TTKPEHEDQG LQAPAPPHAA AEPDLLYYPP GVVVYSGGRY DLLPSSSAY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RXFP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 0.9 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 0.9 nTPM
hypothalamus: 0.1 nTPM
pancreas: 0.1 nTPM
pituitary gland: 0.1 nTPM
salivary gland: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

brain inhibitory neurons: 0.1 nCPM
other brain neurons: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 4.7 nTPM
thalamus: 4.1 nTPM
pons: 3.4 nTPM
hypothalamus: 3 nTPM
medulla oblongata: 2.9 nTPM
amygdala: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: 0.47
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RXFP3 as an antibody target. Whether an autoantibody or antibody against RXFP3 could matter depends on whether native RXFP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RXFP3 is annotated at the cell surface, where native RXFP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RXFP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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