Seroatlas · Human Serome Atlas

RXFP2

Relaxin receptor 2

Also known as: GPR106, GREAT, INSL3R, LGR8, RXFP2_HUMAN, RXFPR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WXD0
Gene
RXFP2
Ensembl
ENSG00000133105
Chromosome
13
Canonical length
754 aa
Protein class
Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

754 residues, UniProt reviewed canonical sequence.

>Q8WXD0|RXFP2
     1  MIVFLVFKHL FSLRLITMFF LLHFIVLINV KDFALTQGSM ITPSCQKGYF PCGNLTKCLP
    61  RAFHCDGKDD CGNGADEENC GDTSGWATIF GTVHGNANSV ALTQECFLKQ YPQCCDCKET
   121  ELECVNGDLK SVPMISNNVT LLSLKKNKIH SLPDKVFIKY TKLKKIFLQH NCIRHISRKA
   181  FFGLCNLQIL YLNHNCITTL RPGIFKDLHQ LTWLILDDNP ITRISQRLFT GLNSLFFLSM
   241  VNNYLEALPK QMCAQMPQLN WVDLEGNRIK YLTNSTFLSC DSLTVLFLPR NQIGFVPEKT
   301  FSSLKNLGEL DLSSNTITEL SPHLFKDLKL LQKLNLSSNP LMYLHKNQFE SLKQLQSLDL
   361  ERIEIPNINT RMFQPMKNLS HIYFKNFRYC SYAPHVRICM PLTDGISSFE DLLANNILRI
   421  FVWVIAFITC FGNLFVIGMR SFIKAENTTH AMSIKILCCA DCLMGVYLFF VGIFDIKYRG
   481  QYQKYALLWM ESVQCRLMGF LAMLSTEVSV LLLTYLTLEK FLVIVFPFSN IRPGKRQTSV
   541  ILICIWMAGF LIAVIPFWNK DYFGNFYGKN GVCFPLYYDQ TEDIGSKGYS LGIFLGVNLL
   601  AFLIIVFSYI TMFCSIQKTA LQTTEVRNCF GREVAVANRF FFIVFSDAIC WIPVFVVKIL
   661  SLFRVEIPDT MTSWIVIFFL PVNSALNPIL YTLTTNFFKD KLKQLLHKHQ RKSIFKIKKK
   721  SLSTSIVWIE DSSSLKLGVL NKITLGDSIM KPVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RXFP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
0.5 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 0.5 nTPM
  • fallopian tube: 0.5 nTPM
  • endometrium: 0.4 nTPM
  • basal ganglia: 0.3 nTPM
  • bone marrow: 0.3 nTPM
  • ovary: 0.2 nTPM

Single-cell type

  • late primary spermatocytes: 8 nCPM
  • early spermatids: 6.6 nCPM
  • brain inhibitory neurons: 4.7 nCPM
  • cardiomyocytes: 4.3 nCPM
  • platelets: 2.8 nCPM
  • other brain neurons: 2.7 nCPM

Immune cell

  • classical monocyte: 1.7 nTPM
  • total PBMC: 0.3 nTPM
  • intermediate monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • basal ganglia: 1.5 nTPM
  • cerebral cortex: 0.8 nTPM
  • hypothalamus: 0.8 nTPM
  • midbrain: 0.6 nTPM
  • thalamus: 0.6 nTPM
  • hippocampal formation: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RXFP2.

Disease | AllUniProt

Conditions RXFP2 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 134 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
gnomAD missense Z
0.89
DepMap mean gene effect
0.17
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RXFP2 as an antibody target. Whether an autoantibody or antibody against RXFP2 could matter depends on whether native RXFP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RXFP2 is annotated at the cell surface, where native RXFP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RXFP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RXFP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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