Seroatlas · Human Serome Atlas

RUSC1-AS1

Putative uncharacterized protein RUSC1-AS1

Also known as: RUAS1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q66K80
Gene: RUSC1-AS1
Canonical length: 236 aa

OverviewNCBI Gene

No narrative summary is available for RUSC1-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>Q66K80|RUSC1-AS1
     1  MEPGGSENAA ALWISEGGRG PGRGPGPEWT SRSLLPQSGP ALQPTPYSQR KGPRETHPDA
    61  LKGGGGWGWG NTQSLSGECR KGVGAGEEKD GAAVSLSTPH LLAASAGLQP APSPLGTAVC
   121  PFSPHSSPSF SHHRTLSLFI SPAPLSCPAP RAQVHRSTPM GRALLTRVLL EPLRPWACPR
   181  LPRSPPGGAQ SGRGGALAQP TLRCAAAPLR AWAWRSSDPP PAFSVFCHPP RGFDIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RUSC1-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.76

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RUSC1-AS1 as an antibody target. Whether an autoantibody or antibody against RUSC1-AS1 could matter depends on whether native RUSC1-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RUSC1-AS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RUSC1-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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