Seroatlas · Human Serome Atlas

RUNDC1

RUN domain-containing protein 1

Also known as: DKFZp761H0421, RUND1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96C34
Gene
RUNDC1
Ensembl
ENSG00000198863
Chromosome
17
Canonical length
613 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

This gene encodes a protein that contains a RUN (RPIP8, UNC-14 and NESCA) domain and a coiled coil domain. The encoded protein may negatively regulate p53 transcriptional activity. This gene is a potential candidate gene for predisposition to glioma in humans. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

613 residues, UniProt reviewed canonical sequence.

>Q96C34|RUNDC1
     1  MAAVEAAAEP VTVVAAVGPK AKDEEEEEEE PLPPCEAVRW APVGAVAEAR PGATAFLEEA
    61  TAEEPGAAPG SPPDSPGRTL RRLRAERRRL DSALLALSSH FAQVQFRLRQ VVRGAPAEQQ
   121  RLLRELEDFA FRGCPHVLGY EGPGDPASDE GDGLPGDRPW LRGEDQSEQE KQERLETQRE
   181  KQKELILQLK TQLDDLETFA YQEGSYDSLP QSVVLERQRV IIDELIKKLD MNLNEDISSL
   241  STEELRQRVD AAVAQIVNPA RVKEQLVEQL KTQIRDLEMF INFIQDEVGS PLQTGGGHCE
   301  CKAGGKTGNG CSRTGSSRTP PGNSKTKAED VKKVRETGLH LMRRALAVLQ IFAVSQFGCA
   361  TGQIPPTLWQ RVQADRDYSP LLKRLEVSVD RVKQLALRQQ PHDHVITSAN LQDLSLGGKD
   421  ELTMAVRKEL TVAVRDLLAH GLYASSPGMS LVMAPIACLL PAFSSAPEAM HPWELFVKYY
   481  HAKNGRAYVE SPARKLSQSF ALPVTGGTVV TPKQSLLTAI HMVLTEHDPF KRSADSELKA
   541  LVCMALNEQR LVSWVNLICK SGSLIEPHYQ PWSYMAHTGF ESALNLLSRL SSLKFSLPVD
   601  LAVRQLKNIK DAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RUNDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 11 nTPM
  • fallopian tube: 9.8 nTPM
  • cerebral cortex: 9.2 nTPM
  • epididymis: 8.3 nTPM
  • prostate: 8.3 nTPM
  • parathyroid gland: 8.2 nTPM

Single-cell type

  • epididymal principal cells: 100 nCPM
  • fallopian tube ciliated cells: 70 nCPM
  • prostatic club cells: 51 nCPM
  • respiratory ciliated cells: 48 nCPM
  • prostatic hillock cells: 45 nCPM
  • prostatic glandular cells: 40 nCPM

Immune cell

  • eosinophil: 7 nTPM
  • basophil: 5.7 nTPM
  • plasmacytoid DC: 4.7 nTPM
  • neutrophil: 4.3 nTPM
  • intermediate monocyte: 3.2 nTPM
  • memory B-cell: 3 nTPM

Brain region

  • cerebral cortex: 21 nTPM
  • basal ganglia: 19 nTPM
  • choroid plexus: 18 nTPM
  • hippocampal formation: 16 nTPM
  • hypothalamus: 15 nTPM
  • white matter: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
gnomAD missense Z
1.13
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RUNDC1 as an antibody target. Whether an autoantibody or antibody against RUNDC1 could matter depends on whether native RUNDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RUNDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RUNDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RUNDC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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