Seroatlas · Human Serome Atlas

RTP5

Receptor-transporting protein 5

Also known as: C2orf85, CXXC11, FLJ33590, RTP5_HUMAN, Z3CXXC5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14D33
Gene: RTP5
Ensembl: ENSG00000188011
Chromosome: 2
Canonical length: 572 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable olfactory receptor binding activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste; protein insertion into membrane; and protein targeting to membrane. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

572 residues, UniProt reviewed canonical sequence.

>Q14D33|RTP5
     1  MDRAGADMWA STFTLAMAER KPQDVWVLLP EHSLVPGCLD GGGVQYLLVG LSRLQCGHCP
    61  GTWDSAHVHV LFHLWWDRAS HRGLVKMRIW GQRCRLCPAP GDCQVRPPGE QPFLSRLVLH
   121  ILQDCYGDGP GPARHPREAY EGCCEACELG VCFLQKAPDP AWSANATKGN FPATAWGGTG
   181  TVSRGKPLST PGDDLGKGGV VIAIPFSLVG TSNDQVPIAE GPAPPAGASL PVTGSCEALV
   241  IGQGSIFLSG DSVAMPGGKG FPVAIGDPLF HGPGLLGSSI QTFELKGFLF KGRGSLCSPV
   301  GVAQGWGPIS LNNGLVPVGK HTPTVFYCVG LSASGEGSLT FPSSLTSIFT NTLSEPTDGP
   361  VATKEASITF PFIFTDVKDA VAEVAEGNGK EGGGQGLVPV GHDALPETNA GGLPSQVKGS
   421  LALPFPADVQ GKDAFTDITE GKEKEGGLVT AGHDAPLEAN AEGPITVSEG CITIPFAVFD
   481  VIKRKGGGHV AYGPQGNGCF SQGYYQKRQL RSRFHKARCG CRREEDERPG RACRRPHAEP
   541  YEDFWIWVSM TVCVFWLMCM CRLNPGIYPQ QV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 50 nTPM
hippocampal formation: 39 nTPM
amygdala: 34 nTPM
basal ganglia: 34 nTPM
cerebral cortex: 20 nTPM
midbrain: 6.4 nTPM

Single-cell type

oligodendrocyte progenitor cells: 27 nCPM
other brain neurons: 19 nCPM
brain inhibitory neurons: 8.6 nCPM
brain excitatory neurons: 7 nCPM
oligodendrocytes: 1.2 nCPM
ependymal cells: 1.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 72 nTPM
hippocampal formation: 64 nTPM
amygdala: 57 nTPM
thalamus: 48 nTPM
cerebral cortex: 42 nTPM
midbrain: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0.02
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTP5 as an antibody target. Whether an autoantibody or antibody against RTP5 could matter depends on whether native RTP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RTP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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