Seroatlas · Human Serome Atlas

RTP2

Receptor-transporting protein 2

Also known as: MGC78665, RTP2_HUMAN, Z3CXXC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5QGT7
Gene: RTP2
Ensembl: ENSG00000198471
Chromosome: 3
Canonical length: 225 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Enables olfactory receptor binding activity. Involved in protein insertion into membrane. Located in cell surface. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>Q5QGT7|RTP2
     1  MCTSLTTCEW KKVFYEKMEV AKPADSWELI IDPNLKPSEL APGWKQYLEQ HASGRFHCSW
    61  CWHTWQSAHV VILFHMFLDR AQRAGSVRMR VFKQLCYECG TARLDESSML EENIEGLVDN
   121  LITSLREQCY EEDGGQYRIH VASRPDSGPH RAEFCEACQE GIVHWKPSEK LLEEEVTTYT
   181  SEASKPRAQA GSGYNFLSLR WCLFWASLCL LVVYLQFSFL SPAFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 1.9 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 1.9 nTPM
testis: 1.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late primary spermatocytes: 16 nCPM
early spermatids: 9.8 nCPM
late spermatids: 3.6 nCPM
epididymal clear cells: 2 nCPM
myonuclei: 0.3 nCPM
peritubular myoid cells: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

spinal cord: 0.2 nTPM
hypothalamus: 0.1 nTPM
pons: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: -0.97
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTP2 as an antibody target. Whether an autoantibody or antibody against RTP2 could matter depends on whether native RTP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTP2 is annotated at the cell surface, where native RTP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RTP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...