Seroatlas · Human Serome Atlas

RTP1

Receptor-transporting protein 1

Also known as: MGC35450, RTP1_HUMAN, Z3CXXC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59025
Gene: RTP1
Ensembl: ENSG00000175077
Chromosome: 3
Canonical length: 263 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Enables olfactory receptor binding activity. Involved in protein insertion into membrane. Located in cell surface. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>P59025|RTP1
     1  MRIFRPWRLR CPALHLPSLS VFSLRWKLPS LTTDETMCKS VTTDEWKKVF YEKMEEAKPA
    61  DSWDLIIDPN LKHNVLSPGW KQYLELHASG RFHCSWCWHT WQSPYVVILF HMFLDRAQRA
   121  GSVRMRVFKQ LCYECGTARL DESSMLEENI EGLVDNLITS LREQCYGERG GQYRIHVASR
   181  QDNRRHRGEF CEACQEGIVH WKPSEKLLEE EATTYTFSRA PSPTKSQDQT GSGWNFCSIP
   241  WCLFWATVLL LIIYLQFSFR SSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 2.1 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 2.1 nTPM
hypothalamus: 1.6 nTPM
testis: 0.5 nTPM
choroid plexus: 0.4 nTPM
hippocampal formation: 0.4 nTPM
spinal cord: 0.3 nTPM

Single-cell type

oocytes: 28 nCPM
late primary spermatocytes: 7.8 nCPM
other brain neurons: 4.5 nCPM
late spermatids: 2.7 nCPM
early spermatids: 2.6 nCPM
sertoli cells: 1.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 6 nTPM
white matter: 4.4 nTPM
basal ganglia: 2.6 nTPM
midbrain: 2.1 nTPM
cerebral cortex: 2 nTPM
thalamus: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: -0.45
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTP1 as an antibody target. Whether an autoantibody or antibody against RTP1 could matter depends on whether native RTP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTP1 is annotated at the cell surface, where native RTP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RTP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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