Seroatlas · Human Serome Atlas

RTL9

Retrotransposon Gag-like protein 9

Also known as: KIAA1318, Mar9, Mart9, RGAG1, RTL9_HUMAN, SIRH10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NET4
Gene
RTL9
Ensembl
ENSG00000243978
Chromosome
X
Canonical length
1388 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for RTL9 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1388 residues, UniProt reviewed canonical sequence.

>Q8NET4|RTL9
     1  MSIPLHSLRF NNTMREENVE PQNKQMAFCR PMTETRADVQ ILHSHVQLPI VSTSASDPGG
    61  TSTQLMTSPV FDTMSAPLMG VPNSGALSPP LMPASDSGAL SPLLMPASDS GALSPLLMPA
   121  LDSGTLSPLL STSEYGVMSP GMMTIPDFGT MSATLMVAPD SAEISPLAMP APSSGVVCTP
   181  IMSTSSSEAM STPLMLAPDS GELSPILMQD MNPGVMSTQP VPAPSSEAMS PLQITDEDTE
   241  AMSKVLMTAL ASGEISSLLM SGTDSEAISS LIMSAVASGG TSPQPTSTQN SGGIPTPLMS
   301  DLDSGIMSSL LMSSPGSEVM STPLLSVPDA GEMSTLPKPA PDAEAMSPAL MTALPSGVMP
   361  TQTMPAPGSG AMSPWSTQNV DSEMMSNPPV RATASGVMSA PPVRALDSGA MSTPLMGAPA
   421  SGNMSTLQKT VPASGAMTTS LMTVPSSGVM STEQMSATAS RVMSAQLTMA KTSGAMPTGS
   481  MKAVAKQYKR ATASGKMSTP LRRAPTSGAM STQPVTATAS ETMSMPQLTV PASGSMSMLQ
   541  MRAPVSEAMS MPQMRTMASG LTSAAQMKAM TSGAMSTPLM TAQTSGSTST LLMRDTASGV
   601  MSCPQMRSLA SGALSKPLMT PKASGTMFTE KMTTTASEAM PTLLMRDTVS GALSMPQMTD
   661  TASGGLSASL MRDTASGAMS TSQMTATVSG GMSMPLMRAQ DPGVMPASLM RAKVSGKMLS
   721  QPMSTQDPGG MSMSPMKSMT AGGMQMNSPT SDVMSTPTVR AWTSETMSTP LMRTSDPGER
   781  PSLLTRASSS GEMSLPLMRA PASGEIATPL RSPAYGAMSA PQMTATASGM MSSMPQVKAP
   841  ISGAMSMPLT RSTASGGMSM PLMRAPDSRV TSTSQMMPTA SGDMCTLPVR APASGGVSSP
   901  LVRAPASGTM STPLRRPSAC ETVSTELMRA SASGHMSTAQ TTAMVSGGMS KPLMRAPASG
   961  TMPMPLMSAM ASGEMSMPLM ETMASGATST LQTSVANSRS MSLSQTTYTV SGRMATAPIR
  1021  ASASGARSTS FMRASVSGSM PMPLPRATAS GCGMGMSMPQ MTATDSRGMS TPLMRASGPG
  1081  TMSTPQTAFG VMSTPEIKAT DSGEASTSHI NITASGSKPT SHMTATTPET AKPPPKEVPS
  1141  FGMLTPALCY LLEEQEAARG SCSVEEEMEI DEEKQMKGFL DDSERMAFLV SLHLGAAERW
  1201  FILQMEVGEP LSHENKSFLR RSQGIYDSLS EIDILSAVLC HPKQGQKSVR QYATDFLLLA
  1261  RHLSWSDAIL RTRFLEGLSE AVTTKMGRIF LKVAGSLKEL IDRSLYTECQ LAEEKDSPGN
  1321  SSQVLPTACK RNNEEAMGNE LSSQQQTEEH QHVSKRCYYL KEHGDPQEGL HDHLGQSTGH
  1381  HQKAHTNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTL9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
7.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 7.5 nTPM
  • hypothalamus: 1.2 nTPM
  • ovary: 1.1 nTPM
  • basal ganglia: 1 nTPM
  • midbrain: 0.7 nTPM
  • cerebellum: 0.5 nTPM

Single-cell type

  • sertoli cells: 226 nCPM
  • pituitary stem cells: 49 nCPM
  • brain inhibitory neurons: 14 nCPM
  • cardiomyocytes: 13 nCPM
  • adrenal medulla cells: 11 nCPM
  • other brain neurons: 11 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 7.4 nTPM
  • midbrain: 5 nTPM
  • hypothalamus: 3.9 nTPM
  • thalamus: 2.4 nTPM
  • cerebral cortex: 2.2 nTPM
  • medulla oblongata: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
1
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Retrotransposon Gag-like protein 9

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTL9 as an antibody target. Whether an autoantibody or antibody against RTL9 could matter depends on whether native RTL9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTL9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RTL9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RTL9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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