Seroatlas · Human Serome Atlas

RTL8A

Retrotransposon Gag-like protein 8A

Also known as: CXX1b, DKFZP564B147, FAM127B, MAR8A, RTL8A_HUMAN, SIRH6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWD3
Gene: RTL8A
Ensembl: ENSG00000203950
Chromosome: X
Canonical length: 113 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for RTL8A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>Q9BWD3|RTL8A
     1  MDGRVQLMKA LLAGPLRPAA RRWRNPIPFP ETFDGDTDRL PEFIVQTSSY MFVDENTFSN
    61  DALKVTFLIT RLTGPALQWV IPYIRKESPL LNDYRGFLAE MKRVFGWEED EDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTL8A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 57 nTPM
cerebellum: 56 nTPM
esophagus: 54 nTPM
pituitary gland: 48 nTPM
hypothalamus: 46 nTPM
ovary: 45 nTPM

Single-cell type

esophageal suprabasal cells: 188 nCPM
esophageal apical cells: 159 nCPM
esophageal basal cells: 148 nCPM
decidual stromal cells: 111 nCPM
fallopian tube ciliated cells: 84 nCPM
migrating cytotrophoblasts: 76 nCPM

Immune cell

non-classical monocyte: 34 nTPM
basophil: 32 nTPM
intermediate monocyte: 28 nTPM
eosinophil: 21 nTPM
classical monocyte: 20 nTPM
myeloid DC: 14 nTPM

Brain region

white matter: 46 nTPM
hypothalamus: 45 nTPM
basal ganglia: 42 nTPM
cerebellum: 41 nTPM
thalamus: 41 nTPM
medulla oblongata: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0.45
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of RTL8A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

UBQLN1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTL8A as an antibody target. Whether an autoantibody or antibody against RTL8A could matter depends on whether native RTL8A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTL8A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RTL8A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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