Seroatlas · Human Serome Atlas

RTL6

Retrotransposon Gag-like protein 6

Also known as: dJ1033E15.2, DKFZp761O17121, LDOC1L, Mar6, Mart6, RTL6_HUMAN, SIRH3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ICC9
Gene: RTL6
Ensembl: ENSG00000188636
Chromosome: 22
Canonical length: 239 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

No narrative summary is available for RTL6 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

239 residues, UniProt reviewed canonical sequence.

>Q6ICC9|RTL6
     1  MVQPQTSKAE SPALAASPNA QMDDVIDTLT SLRLTNSALR REASTLRAEK ANLTNMLESV
    61  MAELTLLRTR ARIPGALQIT PPISSITSNG TRPMTTPPTS LPEPFSGDPG RLAGFLMQMD
   121  RFMIFQASRF PGEAERVAFL VSRLTGEAEK WAIPHMQPDS PLRNNYQGFL AELRRTYKSP
   181  LRHARRAQIR KTSASNRAVR ERQMLCRQLA SAGTGPCPVH PASNGTSPAP ALPARARNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 24 nTPM
ovary: 18 nTPM
tongue: 17 nTPM
parathyroid gland: 17 nTPM
amygdala: 16 nTPM
smooth muscle: 16 nTPM

Single-cell type

late spermatids: 41 nCPM
gastric progenitor cells: 21 nCPM
parietal cells: 19 nCPM
epididymal efferent duct ciliated cells: 19 nCPM
mucous neck cells: 17 nCPM
gonadotrophs: 16 nCPM

Immune cell

MAIT T-cell: 2 nTPM
gdT-cell: 1.8 nTPM
memory CD8 T-cell: 1.5 nTPM
total PBMC: 1.1 nTPM
memory CD4 T-cell: 1 nTPM
naive CD8 T-cell: 1 nTPM

Brain region

thalamus: 49 nTPM
amygdala: 46 nTPM
midbrain: 44 nTPM
cerebral cortex: 43 nTPM
spinal cord: 42 nTPM
medulla oblongata: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0.02
DepMap mean gene effect: 0.21
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTL6 as an antibody target. Whether an autoantibody or antibody against RTL6 could matter depends on whether native RTL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RTL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...