Seroatlas · Human Serome Atlas

RTL5

Retrotransposon Gag-like protein 5

Also known as: KIAA2001, Mar5, Mart5, RGAG4, RTL5_HUMAN, SIRH8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5HYW3
Gene: RTL5
Ensembl: ENSG00000242732
Chromosome: X
Canonical length: 569 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for RTL5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

569 residues, UniProt reviewed canonical sequence.

>Q5HYW3|RTL5
     1  MSEASGNLNS LRMANVALRE ELNALRGENA NLGLQLGRAL AEVNSLRGNV SSYIRWPVPI
    61  VPVLAEENLE FALSEIEVIP GGELPFLCRP PPRAEPDCIS DDLLINVIQD RSTPDGPADP
   121  PLLPIPPPPA LPPPASKEPP PQPPLAPLER PEIEPFSGDP VYLAEFLMQL ETFIADHEVH
   181  FPGGAERVAF LISFFTGEAK DWAISVTQEG SPLHANFPRF LDEIRKEFCG PIPPRVAKKA
   241  IRKLKQGHCT LGSYADAFQF LAQFLSWDDC RLQNQFLKGL SEFFRKELLW STEMADLDEL
   301  ILECVEIERK VRVPKPIPLP GVRNIIFPFA PSPNEEESED EEYYSEDEDQ EARRHRLHSK
   361  DQRKRMRAFQ QEMKEKEEEE MKKEEEMKKK EEKEEEEEEE MKQKEEEEEI RNKNEEEGES
   421  KDEEDEDEDG GQKPEGEPQQ DPGTEETYGE VEEEPLDEAQ DDDLDELMEM EPTFVHASSQ
   481  TSGPTSGYHA ENFLGASPPI IQPSRRRNQN RVPLLEGLPG TNSPFYSSPQ LIRRTGRLGQ
   541  RQVRRRPPVL FRLTPRQGGH RAARGRIRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 9.4 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 9.4 nTPM
pituitary gland: 6.8 nTPM
epididymis: 3.8 nTPM
thyroid gland: 3.7 nTPM
choroid plexus: 3.1 nTPM
ovary: 2.6 nTPM

Single-cell type

corticotrophs: 25 nCPM
pancreatic islet cells: 18 nCPM
lactotrophs: 15 nCPM
somatotrophs: 14 nCPM
gonadotrophs: 12 nCPM
neuroendocrine cells: 12 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 9.9 nTPM
choroid plexus: 8.2 nTPM
hypothalamus: 5.6 nTPM
basal ganglia: 5.5 nTPM
amygdala: 4.8 nTPM
cerebral cortex: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTL5 as an antibody target. Whether an autoantibody or antibody against RTL5 could matter depends on whether native RTL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RTL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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