Seroatlas · Human Serome Atlas

RTL4

Retrotransposon Gag-like protein 4

Also known as: FLJ46608, Mar4, Mart4, RTL4_HUMAN, SIRH11, ZCCHC16

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZR62
Gene: RTL4
Ensembl: ENSG00000187823
Chromosome: X
Canonical length: 310 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to act upstream of or within cognition and norepinephrine metabolic process. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q6ZR62|RTL4
     1  MEKCTKSSST MQVEPSFLQA ENLILRLQMQ HPTTENTAKR GQVMPALATT VMPVPYSLEH
    61  LTQFHGDPAN CSEFLTQVTT YLTALQISNP ANDAQIKLFF DYLSQQLESC GIISGPDKST
   121  LLKQYENLIL EFQQSFGKPT KQEINPLMNA KFDKGDNSSQ QDPATFHLLA QNLICNETNQ
   181  SGQFEKALAD PNQDEESVTD MMDNLPDLIT QCIQLDKKHS DRPELLQSET QLPLLASLIQ
   241  HQALFSPTDP PPKKGPIQLR EGQLPLTPAK RARQQETQLC LYCSQSGHFT RDCLAKRSRA
   301  PATTNNTAHQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 0.9 nTPM

Expression across tissuesHPA

Tissue

liver: 0.9 nTPM
kidney: 0.6 nTPM
bone marrow: 0.3 nTPM
cerebral cortex: 0.1 nTPM
epididymis: 0.1 nTPM
hypothalamus: 0.1 nTPM

Single-cell type

pituitary stem cells: 50 nCPM
pancreatic duct cells: 30 nCPM
hepatocytes: 28 nCPM
cholangiocytes: 16 nCPM
adrenal medulla cells: 11 nCPM
epicardial cells: 9.1 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.2 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

midbrain: 2.4 nTPM
cerebellum: 1.7 nTPM
medulla oblongata: 1.7 nTPM
cerebral cortex: 1.6 nTPM
pons: 1.6 nTPM
thalamus: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTL4 as an antibody target. Whether an autoantibody or antibody against RTL4 could matter depends on whether native RTL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTL4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RTL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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