Seroatlas · Human Serome Atlas

RTL3

Retrotransposon Gag-like protein 3

Also known as: FLJ38865, Mar3, Mart3, RTL3_HUMAN, SIRH9, ZCCHC5, ZHC5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N8U3
Gene: RTL3
Ensembl: ENSG00000179300
Chromosome: X
Canonical length: 475 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Plasma membrane

OverviewNCBI Gene

This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. [provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q8N8U3|RTL3
     1  MVEDLAASYI VLKLENEIRQ AQVQWLMEEN AALQAQIPEL QKSQAAKEYD LLRKSSEAKE
    61  PQKLPEHMNP PAAWEAQKTP EFKEPQKPPE PQDLLPWEPP AAWELQEAPA APESLAPPAT
   121  RESQKPPMAH EIPTVLEGQG PANTQDATIA QEPKNSEPQD PPNIEKPQEA PEYQETAAQL
   181  EFLELPPPQE PLEPSNAQEF LELSAAQESL EGLIVVETSA ASEFPQAPIG LEATDFPLQY
   241  TLTFSGDSQK LPEFLVQLYS YMRVRGHLYP TEAALVSFVG NCFSGRAGWW FQLLLDIQSP
   301  LLEQCESFIP VLQDTFDNPE NMKDANQCIH QLCQGEGHVA THFHLIAQEL NWDESTLWIQ
   361  FQEGLASSIQ DELSHTSPAT NLSDLITQCI SLEEKPDPNP LGKSSSAEGD GPESPPAENQ
   421  PMQAAINCPH ISEAEWVRWH KGRLCLYCGY PGHFARDCPV KPHQALQAGN IQACQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 1.5 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 1.5 nTPM
colon: 0.8 nTPM
stomach: 0.8 nTPM
endometrium: 0.6 nTPM
smooth muscle: 0.5 nTPM
heart muscle: 0.4 nTPM

Single-cell type

leydig cells: 1 nCPM
fibroblasts: 0.8 nCPM
fibro-adipogenic progenitors: 0.3 nCPM
breast secretory cells: 0.1 nCPM
ovarian stromal cells: 0.1 nCPM
pericytes: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTL3 as an antibody target. Whether an autoantibody or antibody against RTL3 could matter depends on whether native RTL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RTL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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