Seroatlas · Human Serome Atlas

RTKN2

Rhotekin-2

Also known as: bA531F24.1, Em:AC024597.2, FLJ39352, PLEKHK1, RTKN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZC4
Gene: RTKN2
Ensembl: ENSG00000182010
Chromosome: 10
Canonical length: 609 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Involved in negative regulation of intrinsic apoptotic signaling pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of non-canonical NF-kappaB signal transduction. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

609 residues, UniProt reviewed canonical sequence.

>Q8IZC4|RTKN2
     1  MEGPSLRGPA LRLAGLPTQQ DCNIQEKIDL EIRMREGIWK LLSLSTQKDQ VLHAVKNLMV
    61  CNARLMAYTS ELQKLEEQIA NQTGRCDVKF ESKERTACKG KIAISDIRIP LMWKDSDHFS
   121  NKERSRRYAI FCLFKMGANV FDTDVVNVDK TITDICFENV TIFNEAGPDF QIKVEVYSCC
   181  TEESSITNTP KKLAKKLKTS ISKATGKKIS SVLQEEDDEM CLLLSSAVFG VKYNLLAHTT
   241  LTLESAEDSF KTHNLSINGN EESSFWLPLY GNMCCRLVAQ PACMAEDAFA GFLNQQQMVE
   301  GLISWRRLYC VLRGGKLYCF YSPEEIEAKV EPALVVPINK ETRIRAMDKD AKKRIHNFSV
   361  INPVPGQAIT QIFAVDNRED LQKWMEAFWQ HFFDLSQWKH CCEELMKIEI MSPRKPPLFL
   421  TKEATSVYHD MSIDSPMKLE SLTDIIQKKI EETNGQFLIG QHEESLPPPW ATLFDGNHQM
   481  VIQKKVLYPA SEPLHDEKGK KRQAPLPPSD KLPFSLKSQS NTDQLVKDNW GKTSVSQTSS
   541  LDTKLSTLMH HLQKPMAAPR KLLPARRNRL SDGEHTDTKT NFEAKPVPAP RQKSIKDILD
   601  PRSWLQAQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTKN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

lung: 73 nTPM
testis: 7.1 nTPM
esophagus: 6.6 nTPM
thymus: 3.6 nTPM
lymph node: 3.2 nTPM
tonsil: 3.2 nTPM

Single-cell type

early spermatids: 496 nCPM
esophageal apical cells: 393 nCPM
late primary spermatocytes: 310 nCPM
alveolar cells type 1: 288 nCPM
oocytes: 138 nCPM
late spermatids: 136 nCPM

Immune cell

T-reg: 17 nTPM
memory CD4 T-cell: 2 nTPM
gdT-cell: 1.1 nTPM
naive CD4 T-cell: 0.6 nTPM
memory CD8 T-cell: 0.4 nTPM
naive CD8 T-cell: 0.3 nTPM

Brain region

cerebral cortex: 8.2 nTPM
white matter: 6 nTPM
cerebellum: 5.8 nTPM
basal ganglia: 5.3 nTPM
thalamus: 4.9 nTPM
amygdala: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: -0.02
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTKN2 as an antibody target. Whether an autoantibody or antibody against RTKN2 could matter depends on whether native RTKN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTKN2 is annotated at the cell surface, where native RTKN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RTKN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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