RTCA

Protein identityUniProt · HPA

UniProt accession

O00442

Gene

RTCA

Ensembl

ENSG00000137996

Chromosome

1

Canonical length

366 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

366 residues, UniProt reviewed canonical sequence.

>O00442|RTCA
     1  MAGPRVEVDG SIMEGGGQIL RVSTALSCLL GLPLRVQKIR AGRSTPGLRP QHLSGLEMIR
    61  DLCDGQLEGA EIGSTEITFT PEKIKGGIHT ADTKTAGSVC LLMQVSMPCV LFAASPSELH
   121  LKGGTNAEMA PQIDYTVMVF KPIVEKFGFI FNCDIKTRGY YPKGGGEVIV RMSPVKQLNP
   181  INLTERGCVT KIYGRAFVAG VLPFKVAKDM AAAAVRCIRK EIRDLYVNIQ PVQEPKDQAF
   241  GNGNGIIIIA ETSTGCLFAG SSLGKRGVNA DKVGIEAAEM LLANLRHGGT VDEYLQDQLI
   301  VFMALANGVS RIKTGPVTLH TQTAIHFAEQ IAKAKFIVKK SEDEEDAAKD TYIIECQGIG
   361  MTNPNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTCA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.22

Highest tissue expression

37 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.13

gnomAD pLI

0

gnomAD missense Z

0.3

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• RNA processing
• negative regulation of optical nerve axon regeneration

Molecular functions

• ATP binding
• RNA binding
• RNA-3'-phosphate cyclase activity

Cellular components

• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• RNA 3'-terminal phosphate cyclase
• RNA 3'-terminal phosphate cyclase, insert domain
• RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
• RNA 3'-terminal phosphate cyclase-like, conserved site
• RNA 3'-terminal phosphate cyclase domain
• RNA 3'-terminal phosphate cyclase, insert domain superfamily
• RNA 3'-terminal phosphate cyclase domain superfamily
• RNA 3'-terminal phosphate cyclase
• RNA 3'-terminal phosphate cyclase (RTC), insert domain
• RNA 3'-terminal phosphate cyclase type 1

KeywordsUniProt

• ATP-binding
• Ligase
• Nucleotide-binding
• Nucleus