RTBDN
Retbindin
Also known as: FLJ36353, RTBDN_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BSG5
- Gene
- RTBDN
- Ensembl
- ENSG00000132026
- Chromosome
- 19
- Canonical length
- 229 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins, Transporters
- Subcellular location
- Endoplasmic reticulum
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
This gene was first identified in a study of human eye tissues. The protein encoded by this gene is preferentially expressed in the retina and may play a role in binding retinoids and other carotenoids as it shares homology with riboflavin binding proteins. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Canonical amino-acid sequenceUniProt
229 residues, UniProt reviewed canonical sequence.
>Q9BSG5|RTBDN
1 MDCRVHMRPI GLTWVLQLTL AWILLEACGG SRPLQARSQQ HHGLAADLGK GKLHLAGPCC
61 PSEMDTTETS GPGNHPERCG VPSPECESFL EHLQRALRSR FRLRLLGVRQ AQPLCEELCQ
121 AWFANCEDDI TCGPTWLPLS EKRGCEPSCL TYGQTFADGT DLCRSALGHA LPVAAPGARH
181 CFNISISAVP RPRPGRRGRE APSRRSRSPR TSILDAAGSG SGSGSGSGPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RTBDN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 268 nTPM
Expression across tissuesHPA
Tissue
- retina: 268 nTPM
- pituitary gland: 32 nTPM
- amygdala: 16 nTPM
- cerebral cortex: 13 nTPM
- hippocampal formation: 12 nTPM
- thymus: 8.1 nTPM
Single-cell type
- rod photoreceptor cells: 19 nCPM
- cone photoreceptor cells: 10 nCPM
- early primary spermatocytes: 1.7 nCPM
- neuroendocrine cells: 1.4 nCPM
- retinal bipolar cells: 1.3 nCPM
- foveolar cells: 0.5 nCPM
Immune cell
- basophil: 0.3 nTPM
- neutrophil: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 23 nTPM
- pons: 16 nTPM
- basal ganglia: 15 nTPM
- hippocampal formation: 13 nTPM
- amygdala: 12 nTPM
- white matter: 10 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.67
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.2
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
- riboflavin transmembrane transporter activity
- signaling receptor activity
- riboflavin binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RTBDN as an antibody target. Whether an autoantibody or antibody against RTBDN could matter depends on whether native RTBDN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RTBDN is annotated at the cell surface, where native RTBDN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label RTBDN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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