Seroatlas · Human Serome Atlas

RSRP1

Arginine/serine-rich protein 1

Also known as: C1orf63, DJ465N24.2.1, RSRP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUV0
Gene: RSRP1
Ensembl: ENSG00000117616
Chromosome: 1
Canonical length: 290 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Involved in spliceosomal complex assembly. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

290 residues, UniProt reviewed canonical sequence.

>Q9BUV0|RSRP1
     1  MSNYVNDMWP GSPQEKDSPS TSRSGGSSRL SSRSRSRSFS RSSRSHSRVS SRFSSRSRRS
    61  KSRSRSRRRH QRKYRRYSRS YSRSRSRSRS RRYRERRYGF TRRYYRSPSR YRSRSRSRSR
   121  SRGRSYCGRA YAIARGQRYY GFGRTVYPEE HSRWRDRSRT RSRSRTPFRL SEKDRMELLE
   181  IAKTNAAKAL GTTNIDLPAS LRTVPSAKET SRGIGVSSNG AKPELSEKVT EDGTRNPNEK
   241  PTQQRSIAFS SNNSVAKPIQ KSAKAATEEA SSRSPKIDQK KSPYGLWIPI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSRP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 66 nTPM
kidney: 65 nTPM
pituitary gland: 60 nTPM
prostate: 59 nTPM
vagina: 56 nTPM
cervix: 54 nTPM

Single-cell type

neutrophils: 606 nCPM
lacrimal acinar cells: 428 nCPM
breast lactating cells: 421 nCPM
enterocytes: 404 nCPM
colonocytes: 361 nCPM
innate lymphoid cells: 358 nCPM

Immune cell

basophil: 150 nTPM
neutrophil: 131 nTPM
eosinophil: 88 nTPM
myeloid DC: 60 nTPM
classical monocyte: 57 nTPM
non-classical monocyte: 55 nTPM

Brain region

medulla oblongata: 72 nTPM
white matter: 64 nTPM
cerebral cortex: 52 nTPM
basal ganglia: 48 nTPM
pons: 47 nTPM
choroid plexus: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

spliceosomal complex assembly

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Arginine/Serine-Rich protein 1
Arginine/serine-rich protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RSRP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CLK2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RSRP1 as an antibody target. Whether an autoantibody or antibody against RSRP1 could matter depends on whether native RSRP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RSRP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RSRP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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