Seroatlas · Human Serome Atlas

RSPH14

Radial spoke head 14 homolog

Also known as: RSP14_HUMAN, RTDR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UHP6
Gene: RSPH14
Ensembl: ENSG00000100218
Chromosome: 22
Canonical length: 348 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

This gene encodes a protein with no known function but with slight similarity to a yeast vacuolar protein. The gene is located in a region deleted in pediatric rhabdoid tumors of the brain, kidney and soft tissues, but mutations in this gene have not been associated with the disease. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>Q9UHP6|RSPH14
     1  MAHSQNSLEL PININATQIT TAYGHRALPK LKEELQSEDL QTRQKALMAL CDLMHDPECI
    61  YKAMNIGCME NLKALLKDSN SMVRIKTTEV LHITASHSVG RYAFLEHDIV LALSFLLNDP
   121  SPVCRGNLYK AYMQLVQVPR GAQEIISKGL ISSLVWKLQV EVEEEEFQEF ILDTLVLCLQ
   181  EDATEALGSN VVLVLKQKLL SANQNIRSKA ARALLNVSIS REGKKQVCHF DVIPILVHLL
   241  KDPVEHVKSN AAGALMFATV ITEGKYAALE AQAIGLLLEL LHSPMTIARL NATKALTMLA
   301  EAPEGRKALQ THVPTFRAME VETYEKPQVA EALQRAARIA ISVIEFKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSPH14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

testis: 25 nTPM
fallopian tube: 12 nTPM
retina: 11 nTPM
choroid plexus: 9.7 nTPM
basal ganglia: 7.5 nTPM
kidney: 6.8 nTPM

Single-cell type

late spermatids: 416 nCPM
early spermatids: 191 nCPM
respiratory ciliated cells: 138 nCPM
late primary spermatocytes: 85 nCPM
megakaryocytes: 68 nCPM
platelets: 63 nCPM

Immune cell

neutrophil: 7.8 nTPM
non-classical monocyte: 1.8 nTPM
total PBMC: 0.6 nTPM
naive CD4 T-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

cerebral cortex: 20 nTPM
midbrain: 19 nTPM
hypothalamus: 16 nTPM
choroid plexus: 15 nTPM
basal ganglia: 15 nTPM
white matter: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

radial spoke

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RSPH14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

AP3M1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RSPH14 as an antibody target. Whether an autoantibody or antibody against RSPH14 could matter depends on whether native RSPH14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RSPH14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RSPH14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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