Seroatlas · Human Serome Atlas

RSKR

Ribosomal protein S6 kinase-related protein

Also known as: KS6R_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LW2
Gene: RSKR
Canonical length: 410 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for RSKR in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

410 residues, UniProt reviewed canonical sequence.

>Q96LW2|RSKR
     1  MGAVSCRQGQ HTQQGEHTRV AVPHKQGGNI RGPWARGWKS LWTGLGTIRS DLEELWELRG
    61  HHYLHQESLK PAPVLVEKPL PEWPVPQFIN LFLPEFPIRP IRGQQQLKIL GLVAKGSFGT
   121  VLKVLDCTQK AVFAVKVVPK VKVLQRDTVR QCKEEVSIQR QINHPFVHSL GDSWQGKRHL
   181  FIMCSYCSTD LYSLWSAVGC FPEASIRLFA AELVLVLCYL HDLGIMHRDV KMENILLDER
   241  GHLKLTDFGL SRHVPQGAQA YTICGTLQYM APEVLSGGPY NHAADWWSLG VLLFSLATGK
   301  FPVAAERDHV AMLASVTHSD SEIPASLNQG LSLLLHELLC QNPLHRLRYL HHFQVHPFFR
   361  GVAFDPELLQ KQPVNFVTET QATQPSSAET MPFDDFDCDL ESFLLYPIPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSKR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 5.3 nTPM

Expression across tissuesHPA

Tissue

retina: 5.3 nTPM
bone marrow: 1.5 nTPM
cerebellum: 1.3 nTPM
testis: 1.1 nTPM
kidney: 0.9 nTPM
appendix: 0.7 nTPM

Single-cell type

late spermatids: 29 nCPM
rod photoreceptor cells: 21 nCPM
early spermatids: 20 nCPM
cardiomyocytes: 17 nCPM
enterocytes: 15 nCPM
cone photoreceptor cells: 15 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 1.5 nTPM
white matter: 1.5 nTPM
cerebellum: 1.3 nTPM
cerebral cortex: 1.3 nTPM
thalamus: 1.3 nTPM
medulla oblongata: 1.2 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Protein kinase domain
Serine/threonine-protein kinase, active site
Protein kinase-like domain superfamily
Protein kinase domain
Serine/Threonine Kinase AGC, catalytic domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RSKR as an antibody target. Whether an autoantibody or antibody against RSKR could matter depends on whether native RSKR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RSKR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RSKR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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