Seroatlas · Human Serome Atlas

RSC1A1

Regulatory solute carrier protein family 1 member 1

Also known as: RS1, RSCA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92681
Gene: RSC1A1
Ensembl: ENSG00000215695
Chromosome: 1
Canonical length: 617 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cell Junctions

OverviewNCBI Gene

The protein encoded by this intronless gene inhibits the expression of the solute carrier family 5 (sodium/glucose cotransporter), member 1 gene (SLC5A1) and downregulates exocytosis of the SLC5A1 protein. The encoded protein is sometimes found coating the trans-Golgi network and other times is localized to the nucleus, depending on the cell cycle stage. This protein also inhibits the expression of solute carrier family 22 (organic cation transporter), member 2 (SLC22A2). [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

617 residues, UniProt reviewed canonical sequence.

>Q92681|RSC1A1
     1  MSSLPTSDGF NHPARSSGQS PDVGNPMSLA RSVSASVCPI KPSDSDRIEP KAVKALKASA
    61  EFQLNSEKKE HLSLQDLSDH ASSADHAPTD QSPAMPMQNS SEEITVAGNL EKSAERSTQG
   121  LKFHLHTRQE ASLSVTSTRM HEPQMFLGEK DWHPENQNLS QVSDPQQHEE PGNEQYEVAQ
   181  QKASHDQEYL CNIGDLELPE ERQQNQHKIV DLEATMKGNG LPQNVDPPSA KKSIPSSECS
   241  GCSNSETFME IDTAQQSLVT LLNSTGRQNA NVKNIGALDL TLDNPLMEVE TSKCNPSSEI
   301  LNDSISTQDL QPPETNVEIP GTNKEYGHYS SPSLCGSCQP SVESAEESCP SITAALKELH
   361  ELLVVSSKPA SENTSEEVIC QSETIAEGQT SIKDLSERWT QNEHLTQNEQ CPQVSFHQAI
   421  SVSVETEKLT GTSSDTGREA VENVNFRSLG DGLSTDKEGV PKSRESINKN RSVTVTSAKT
   481  SNQLHCTLGV EISPKLLAGE EDALNQTSEQ TKSLSSNFIL VKDLGQGIQN SVTDRPETRE
   541  NVCPDASRPL LEYEPPTSHP SSSPAILPPL IFPATDIDRI LRAGFTLQEA LGALHRVGGN
   601  ADLALLVLLA KNIVVPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSC1A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 6.9 nTPM

Expression across tissuesHPA

Tissue

liver: 6.9 nTPM
bone marrow: 4.1 nTPM
kidney: 3.8 nTPM
esophagus: 3.7 nTPM
tonsil: 3.1 nTPM
smooth muscle: 3 nTPM

Single-cell type

choroid plexus epithelial cells: 1.5 nCPM
microglia: 1.3 nCPM
oligodendrocytes: 0.8 nCPM
ependymal cells: 0.7 nCPM
brain excitatory neurons: 0.6 nCPM
brain inhibitory neurons: 0.5 nCPM

Immune cell

intermediate monocyte: 0.8 nTPM
myeloid DC: 0.7 nTPM
T-reg: 0.6 nTPM
memory CD8 T-cell: 0.5 nTPM
NK-cell: 0.4 nTPM
total PBMC: 0.4 nTPM

Brain region

white matter: 11 nTPM
cerebral cortex: 8.5 nTPM
choroid plexus: 8.4 nTPM
medulla oblongata: 7.4 nTPM
pons: 7.4 nTPM
thalamus: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: -0.24
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of D-glucose transmembrane transport
negative regulation of Golgi to plasma membrane protein transport
negative regulation of protein localization to plasma membrane
negative regulation of transport
negative regulation of nucleoside transport

Molecular functions

sodium channel inhibitor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ubiquitin-associated domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RSC1A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

YRDC

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RSC1A1 as an antibody target. Whether an autoantibody or antibody against RSC1A1 could matter depends on whether native RSC1A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RSC1A1 is annotated at the cell surface, where native RSC1A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RSC1A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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