Seroatlas · Human Serome Atlas

RRP36

Ribosomal RNA processing protein 36 homolog

Also known as: C6orf153, dJ20C7.4, RRP36_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EU6
Gene: RRP36
Ensembl: ENSG00000124541
Chromosome: 6
Canonical length: 259 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

RRP36 functions at an early stage in the processing of 35S preribosomal RNA into the mature 18S species (Gerus et al., 2010 [PubMed 20038530]).[supplied by OMIM, Jul 2010]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>Q96EU6|RRP36
     1  MPGANYRAGA GAGAGARRPR GARDREEDGG GLEPAAVARD LLRGTSNMSF EELLELQSQV
    61  GTKTYKQLVA GNSPKKQASR PPIQNACVAD KHRPLEMSAK IRVPFLRQVV PISKKVARDP
   121  RFDDLSGEYN PEVFDKTYQF LNDIRAKEKE LVKKQLKKHL SGEEHEKLQQ LLQRMEQQEM
   181  AQQERKQQQE LHLALKQERR AQAQQGHRPY FLKKSEQRQL ALAEKFKELK RSKKLENFLS
   241  RKRRRNAGKD RRHLPLSKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRP36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 48 nTPM
esophagus: 36 nTPM
liver: 35 nTPM
pancreas: 34 nTPM
tonsil: 33 nTPM
kidney: 33 nTPM

Single-cell type

megakaryocytes: 118 nCPM
alveolar cells type 1: 60 nCPM
erythrocyte progenitors: 56 nCPM
extravillous trophoblasts: 55 nCPM
breast lactating cells: 53 nCPM
plasma cells: 53 nCPM

Immune cell

plasmacytoid DC: 6 nTPM
memory B-cell: 4.5 nTPM
naive CD8 T-cell: 4.5 nTPM
memory CD8 T-cell: 4.2 nTPM
gdT-cell: 3.4 nTPM
intermediate monocyte: 3 nTPM

Brain region

hypothalamus: 29 nTPM
pons: 29 nTPM
cerebral cortex: 27 nTPM
cerebellum: 27 nTPM
medulla oblongata: 27 nTPM
midbrain: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: -0.08
DepMap mean gene effect: -0.4
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

rRNA biogenesis protein RRP36
rRNA biogenesis protein RRP36

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RRP36 as an antibody target. Whether an autoantibody or antibody against RRP36 could matter depends on whether native RRP36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RRP36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RRP36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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