Seroatlas · Human Serome Atlas

RRN3P2

Putative RRN3-like protein RRN3P2

Also known as: RN3P2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NIE6
Gene: RRN3P2
Canonical length: 340 aa

OverviewNCBI Gene

No narrative summary is available for RRN3P2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>A6NIE6|RRN3P2
     1  MAAPLLHTRL PGDAAASPSA VKMLGASRTG ISNMRALEND FFNSPPRKTV QFGGTVTEVL
    61  LKYKTGETND FELLKNQLLD PDIKDDQIIN WLLEFRSSIM YLTKDFEQLI SIILRLPWLN
   121  RSQTVVEEYL AFLGNLVSAQ TVFLRPCLSM IASHFVPPRV IIKEGDVDVS DSDDEDDNLP
   181  ANFDTSQSLA NNSKICTIEC YVHNLLRISV YFPTLRHEIL ELIIEKLLKL DVNASRQGIE
   241  DAEETANQTC GGTDSTEGLC NMGFAEAFLE PLWKKLQDPS NPAIIRQAAG NYIGSFLARA
   301  KFIPLMIREQ RHSAMLLSMD HFTQPAKLCS TPLFLDTSSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRN3P2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

transcription initiation at RNA polymerase I promoter

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RRN3P2 as an antibody target. Whether an autoantibody or antibody against RRN3P2 could matter depends on whether native RRN3P2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RRN3P2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RRN3P2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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