Seroatlas · Human Serome Atlas

RRN3P1

Putative RRN3-like protein RRN3P1

Also known as: RN3P1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2M238
Gene: RRN3P1
Canonical length: 152 aa

OverviewNCBI Gene

No narrative summary is available for RRN3P1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

152 residues, UniProt reviewed canonical sequence.

>Q2M238|RRN3P1
     1  MGFAEAFLEH LWKNLQDPSN PAIIRQAAGN YIGSFLARAK FISLITVKPC LDLLVNWLHI
    61  YLNNQDSGTK AFCDVALHGP FYSACQAVFY TFVFRHKQLL SGNLKEGLQY PQSLNFERIV
   121  MSQLNPLKIC LPSVVNFFAA ITKMKTCGYG WW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRN3P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

transcription initiation at RNA polymerase I promoter

Molecular functions

RNA polymerase I general transcription initiation factor activity

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RRN3P1 as an antibody target. Whether an autoantibody or antibody against RRN3P1 could matter depends on whether native RRN3P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RRN3P1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RRN3P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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