Seroatlas · Human Serome Atlas

RRH

Visual pigment-like receptor peropsin

Also known as: OPSX_HUMAN, peropsin

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14718
Gene: RRH
Ensembl: ENSG00000180245
Chromosome: 4
Canonical length: 337 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes opsin 5 and retinal G protein coupled receptor. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>O14718|RRH
     1  MLRNNLGNSS DSKNEDGSVF SQTEHNIVAT YLIMAGMISI ISNIIVLGIF IKYKELRTPT
    61  NAIIINLAVT DIGVSSIGYP MSAASDLYGS WKFGYAGCQV YAGLNIFFGM ASIGLLTVVA
   121  VDRYLTICLP DVGRRMTTNT YIGLILGAWI NGLFWALMPI IGWASYAPDP TGATCTINWR
   181  KNDRSFVSYT MTVIAINFIV PLTVMFYCYY HVTLSIKHHT TSDCTESLNR DWSDQIDVTK
   241  MSVIMICMFL VAWSPYSIVC LWASFGDPKK IPPPMAIIAP LFAKSSTFYN PCIYVVANKK
   301  FRRAMLAMFK CQTHQTMPVT SILPMDVSQN PLASGRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

retina: 70 nTPM
cerebellum: 0.8 nTPM
choroid plexus: 0.5 nTPM
amygdala: 0.3 nTPM
cerebral cortex: 0.3 nTPM
hippocampal formation: 0.3 nTPM

Single-cell type

retinal pigment epithelial cells: 350 nCPM
müller glia: 233 nCPM
ependymal cells: 13 nCPM
brain inhibitory neurons: 8.2 nCPM
brain excitatory neurons: 7.8 nCPM
choroid plexus epithelial cells: 7.5 nCPM

Immune cell

T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 1.8 nTPM
white matter: 1.6 nTPM
basal ganglia: 1.4 nTPM
cerebellum: 1.3 nTPM
hippocampal formation: 1.3 nTPM
medulla oblongata: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: -0.1
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RRH as an antibody target. Whether an autoantibody or antibody against RRH could matter depends on whether native RRH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RRH is annotated at the cell surface, where native RRH is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RRH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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