RPUSD2
Pseudouridylate synthase RPUSD2
Also known as: C15orf19, C18B11, FLJ31409, PUS9, RUSD2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IZ73
- Gene
- RPUSD2
- Ensembl
- ENSG00000166133
- Chromosome
- 15
- Canonical length
- 545 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Microtubules
OverviewNCBI Gene
Enables pseudouridine synthase activity. Involved in mRNA pseudouridine synthesis. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
545 residues, UniProt reviewed canonical sequence.
>Q8IZ73|RPUSD2
1 MWLDRRGWLR VLGHWRYDLR RPSFTRTWSG DKGPMAETVS TQVGTEGGLR ASHQQNGDAG
61 GDAKVELSPG PPKPAGREVE PAPVGGEHPS AAAPGPGKHK KRRGATRERV VPPPKKRRTG
121 VSFGDEHFAE TSYYFEGGLR KVRPYYFDFR TYCKGRWVGH SLLHVFSTEF RAQPLAYYEA
181 AVRAGRLQLN EKPVQDLNIV LKDNDFLRNT VHRHEPPVTA EPIRLLAENE DVVVVDKPSS
241 IPVHPCGRFR HNTVIFILGK EHQLKELHPL HRLDRLTSGV LMFAKTAAVS ERIHEQVRDR
301 QLEKEYVCRV EGEFPTEEVT CKEPILVVSY KVGVCRVDPR GKPCETVFQR LSYNGQSSVV
361 RCRPLTGRTH QIRVHLQFLG HPILNDPIYN SVAWGPSRGR GGYIPKTNEE LLRDLVAEHQ
421 AKQSLDVLDL CEGDLSPGLT DSTAPSSELG KDDLEELAAA AQKMEEVAEA APQELDTIAL
481 ASEKAVETDV MNQETDPLCA ECRLVRQDPL PQDLVMFLHA LRYKGPGFEY FSPMPAWAQD
541 DWQKDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RPUSD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 14 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 14 nTPM
- bone marrow: 9.1 nTPM
- skin: 9.1 nTPM
- heart muscle: 9 nTPM
- basal ganglia: 8.9 nTPM
- endometrium: 8.7 nTPM
Single-cell type
- differentiating spermatogonia: 19 nCPM
- cytotrophoblasts: 19 nCPM
- megakaryocytes: 19 nCPM
- migrating cytotrophoblasts: 17 nCPM
- undifferentiated spermatogonia: 17 nCPM
- esophageal basal cells: 16 nCPM
Immune cell
- naive B-cell: 36 nTPM
- NK-cell: 34 nTPM
- memory B-cell: 28 nTPM
- naive CD4 T-cell: 27 nTPM
- T-reg: 26 nTPM
- memory CD8 T-cell: 25 nTPM
Brain region
- basal ganglia: 12 nTPM
- cerebral cortex: 12 nTPM
- white matter: 12 nTPM
- choroid plexus: 12 nTPM
- cerebellum: 11 nTPM
- pons: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.09
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.07
- DepMap mean gene effect
- -0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RPUSD2 as an antibody target. Whether an autoantibody or antibody against RPUSD2 could matter depends on whether native RPUSD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RPUSD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RPUSD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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