RPS6KA6

Protein identityUniProt · HPA

UniProt accession

Q9UK32

Gene

RPS6KA6

Ensembl

ENSG00000072133

Chromosome

X

Canonical length

745 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Mitochondria

OverviewNCBI Gene

This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

745 residues, UniProt reviewed canonical sequence.

>Q9UK32|RPS6KA6
     1  MLPFAPQDEP WDREMEVFSG GGASSGEVNG LKMVDEPMEE GEADSCHDEG VVKEIPITHH
    61  VKEGYEKADP AQFELLKVLG QGSFGKVFLV RKKTGPDAGQ LYAMKVLKKA SLKVRDRVRT
   121  KMERDILVEV NHPFIVKLHY AFQTEGKLYL ILDFLRGGDV FTRLSKEVLF TEEDVKFYLA
   181  ELALALDHLH QLGIVYRDLK PENILLDEIG HIKLTDFGLS KESVDQEKKA YSFCGTVEYM
   241  APEVVNRRGH SQSADWWSYG VLMFEMLTGT LPFQGKDRNE TMNMILKAKL GMPQFLSAEA
   301  QSLLRMLFKR NPANRLGSEG VEEIKRHLFF ANIDWDKLYK REVQPPFKPA SGKPDDTFCF
   361  DPEFTAKTPK DSPGLPASAN AHQLFKGFSF VATSIAEEYK ITPITSANVL PIVQINGNAA
   421  QFGEVYELKE DIGVGSYSVC KRCIHATTNM EFAVKIIDKS KRDPSEEIEI LMRYGQHPNI
   481  ITLKDVFDDG RYVYLVTDLM KGGELLDRIL KQKCFSEREA SDILYVISKT VDYLHCQGVV
   541  HRDLKPSNIL YMDESASADS IRICDFGFAK QLRGENGLLL TPCYTANFVA PEVLMQQGYD
   601  AACDIWSLGV LFYTMLAGYT PFANGPNDTP EEILLRIGNG KFSLSGGNWD NISDGAKDLL
   661  SHMLHMDPHQ RYTAEQILKH SWITHRDQLP NDQPKRNDVS HVVKGAMVAT YSALTHKTFQ
   721  PVLEPVAASS LAQRRSMKKR TSTGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS6KA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

7.6 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.3

gnomAD pLI

0.99

gnomAD missense Z

1.87

DepMap mean gene effect

0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• central nervous system development
• DNA damage response, signal transduction by p53 class mediator
• negative regulation of ERK1 and ERK2 cascade
• negative regulation of mesoderm development
• signal transduction
• TORC1 signaling
• negative regulation of embryonic development

Molecular functions

• ATP binding
• magnesium ion binding
• protein kinase activity
• protein serine kinase activity
• ribosomal protein S6 kinase activity

Cellular components

• cytoplasm
• cytosol
• fibrillar center
• mitochondrion
• nucleolus
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• AGC-kinase, C-terminal
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Ribosomal protein S6 kinase II
• Protein kinase, ATP binding site
• Protein kinase, C-terminal
• Ribosomal S6 kinase, N-terminal catalytic domain
• Protein kinase domain
• Protein kinase C terminal domain

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Kinase
• Magnesium
• Metal-binding
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Repeat
• Serine/threonine-protein kinase
• Transferase

InteractionsUniProt · HPA

Protein binding partners of RPS6KA6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAPK3