Seroatlas · Human Serome Atlas

RPS29

Small ribosomal subunit protein uS14

Also known as: RS29_HUMAN, S29, uS14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62273
Gene
RPS29
Ensembl
ENSG00000213741
Chromosome
14
Canonical length
56 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

Canonical amino-acid sequenceUniProt

56 residues, UniProt reviewed canonical sequence.

>P62273|RPS29
     1  MGHQQLYWSH PRKFGQGSRS CRVCSNRHGL IRKYGLNMCR QCFRQYAKDI GFIKLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
4,679 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 4,679 nTPM
  • skin: 4,434 nTPM
  • pancreas: 4,275 nTPM
  • spleen: 3,996 nTPM
  • skeletal muscle: 3,554 nTPM
  • esophagus: 3,207 nTPM

Single-cell type

  • enteric stem cells: 7,440 nCPM
  • enteric transient amplifying cells: 7,357 nCPM
  • gastric chief cells: 6,582 nCPM
  • goblet cells: 6,552 nCPM
  • parietal cells: 5,583 nCPM
  • paneth cells: 5,577 nCPM

Immune cell

  • total PBMC: 26,762 nTPM
  • naive CD4 T-cell: 13,527 nTPM
  • memory CD4 T-cell: 12,213 nTPM
  • memory B-cell: 11,718 nTPM
  • naive CD8 T-cell: 11,407 nTPM
  • naive B-cell: 10,386 nTPM

Brain region

  • spinal cord: 463 nTPM
  • white matter: 426 nTPM
  • thalamus: 400 nTPM
  • basal ganglia: 356 nTPM
  • medulla oblongata: 343 nTPM
  • pons: 335 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPS29.

Disease | AllUniProt

Conditions RPS29 is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 73 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Diamond-Blackfan anemia 13

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0.29
gnomAD missense Z
1.02
DepMap mean gene effect
-2.82
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS29 as an antibody target. Whether an autoantibody or antibody against RPS29 could matter depends on whether native RPS29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS29. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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