RPS27L
Ribosomal protein eS27-like
Also known as: RS27L_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q71UM5
- Gene
- RPS27L
- Ensembl
- ENSG00000185088
- Chromosome
- 15
- Canonical length
- 84 aa
- Protein class
- Predicted intracellular proteins, Ribosomal proteins
- Subcellular location
- Nucleoli,Endoplasmic reticulum,Cytosol
OverviewNCBI Gene
This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the encoded protein may be a component of the 40S ribosomal subunit. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
84 residues, UniProt reviewed canonical sequence.
>Q71UM5|RPS27L
1 MPLARDLLHP SLEEEKKKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA QTVVLCVGCS
61 TVLCQPTGGK ARLTEGCSFR RKQHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RPS27L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 261 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 261 nTPM
- liver: 248 nTPM
- adrenal gland: 232 nTPM
- pancreas: 231 nTPM
- choroid plexus: 216 nTPM
- kidney: 206 nTPM
Single-cell type
- extravillous trophoblasts: 1,859 nCPM
- parietal cells: 1,448 nCPM
- enterocytes: 1,292 nCPM
- hepatocytes: 1,069 nCPM
- gastric chief cells: 997 nCPM
- gastric progenitor cells: 938 nCPM
Immune cell
- T-reg: 306 nTPM
- basophil: 265 nTPM
- non-classical monocyte: 199 nTPM
- total PBMC: 166 nTPM
- eosinophil: 165 nTPM
- memory CD4 T-cell: 151 nTPM
Brain region
- choroid plexus: 87 nTPM
- white matter: 61 nTPM
- spinal cord: 52 nTPM
- hypothalamus: 49 nTPM
- medulla oblongata: 48 nTPM
- thalamus: 43 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.27
- gnomAD pLI
- 0.1
- gnomAD missense Z
- 0.79
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- DNA damage response, signal transduction by p53 class mediator
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- mitotic G1 DNA damage checkpoint signaling
- positive regulation of translation
- ribosomal small subunit assembly
- translation
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RPS27L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RPS27L as an antibody target. Whether an autoantibody or antibody against RPS27L could matter depends on whether native RPS27L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RPS27L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RPS27L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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