Seroatlas · Human Serome Atlas

RPS19BP1

Active regulator of SIRT1

Also known as: AROS_HUMAN, FLJ21770, MGC52010

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WX3
Gene: RPS19BP1
Ensembl: ENSG00000187051
Chromosome: 22
Canonical length: 136 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Enables enzyme binding activity. Involved in ribosomal small subunit biogenesis. Located in cytosol; nucleolus; and nucleoplasm. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

136 residues, UniProt reviewed canonical sequence.

>Q86WX3|RPS19BP1
     1  MSAALLRRGL ELLAASEAPR DPPGQAKPRG APVKRPRKTK AIQAQKLRNS AKGKVPKSAL
    61  DEYRKRECRD HLRVNLKFLT RTRSTVAESV SQQILRQNRG RKACDRPVAK TKKKKAEGTV
   121  FTEEDFQKFQ QEYFGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS19BP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 179 nTPM

Expression across tissuesHPA

Tissue

liver: 179 nTPM
midbrain: 170 nTPM
amygdala: 164 nTPM
hippocampal formation: 162 nTPM
kidney: 155 nTPM
cerebral cortex: 154 nTPM

Single-cell type

megakaryocytes: 328 nCPM
esophageal apical cells: 326 nCPM
esophageal suprabasal cells: 288 nCPM
epididymal principal cells: 287 nCPM
extravillous trophoblasts: 281 nCPM
esophageal basal cells: 254 nCPM

Immune cell

plasmacytoid DC: 194 nTPM
eosinophil: 188 nTPM
naive B-cell: 175 nTPM
neutrophil: 170 nTPM
T-reg: 166 nTPM
memory B-cell: 161 nTPM

Brain region

thalamus: 76 nTPM
cerebellum: 71 nTPM
medulla oblongata: 70 nTPM
spinal cord: 68 nTPM
pons: 65 nTPM
basal ganglia: 65 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: -0.66
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ribosomal small subunit biogenesis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Active regulator of SIRT1
Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS19BP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS19BP1 as an antibody target. Whether an autoantibody or antibody against RPS19BP1 could matter depends on whether native RPS19BP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS19BP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS19BP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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