Seroatlas · Human Serome Atlas

RPRML

Reprimo-like protein

Also known as: MGC43894, RPRML_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N4K4
Gene
RPRML
Ensembl
ENSG00000179673
Chromosome
17
Canonical length
120 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

120 residues, UniProt reviewed canonical sequence.

>Q8N4K4|RPRML
     1  MNATFLNHSG LEEVDGVGGG AGAALGNRTH GLGTWLGCCP GGAPLAASDG VPAGLAPDER
    61  SLWVSRVAQI AVLCVLSLTV VFGVFFLGCN LLIKSESMIN FLVQERRPSK DVGAAILGLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPRML can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 47 nTPM
  • cerebral cortex: 22 nTPM
  • amygdala: 11 nTPM
  • hippocampal formation: 11 nTPM
  • cerebellum: 7.2 nTPM
  • hypothalamus: 3.3 nTPM

Single-cell type

  • epididymal principal cells: 60 nCPM
  • neuroendocrine cells: 48 nCPM
  • epididymal efferent duct ciliated cells: 36 nCPM
  • brain excitatory neurons: 16 nCPM
  • brain inhibitory neurons: 15 nCPM
  • fallopian tube ciliated cells: 5.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 35 nTPM
  • cerebral cortex: 28 nTPM
  • white matter: 20 nTPM
  • hippocampal formation: 14 nTPM
  • hypothalamus: 13 nTPM
  • amygdala: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.51
gnomAD pLI
0.46
gnomAD missense Z
0.4
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPRML as an antibody target. Whether an autoantibody or antibody against RPRML could matter depends on whether native RPRML is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPRML is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPRML as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPRML. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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