RPP38-DT
Putative uncharacterized protein RPP38-DT
Also known as: CJ111_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for RPP38-DT in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
155 residues, UniProt reviewed canonical sequence.
>Q8N326|RPP38-DT
1 MESLQTPQHR ENQDKREKEY GVKHMPMGNN AGNLEPEKRK AVRVALSSAT AAQNIPSSVH
61 CGCSKQWRLR LPSESLQSRG QVMKRPNNIL KLRNLDLLIY PWPELRRRQV ASDLMSLLLL
121 PAFSGLTWAP FLFLFTYLPP FLNLLTVGFV SYFLVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RPP38-DT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.62
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RPP38-DT as an antibody target. Whether an autoantibody or antibody against RPP38-DT could matter depends on whether native RPP38-DT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RPP38-DT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RPP38-DT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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