RPL41
Small ribosomal subunit protein eS32
Also known as: L41, RS32_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P62945
- Gene
- RPL41
- Ensembl
- ENSG00000229117
- Chromosome
- 12
- Canonical length
- 25 aa
- Protein class
- Predicted intracellular proteins, Ribosomal proteins
- Subcellular location
- Endoplasmic reticulum
OverviewNCBI Gene
Enables mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Involved in cytoplasmic translation. Located in endoplasmic reticulum. Part of cytosolic large ribosomal subunit. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
25 residues, UniProt reviewed canonical sequence.
>P62945|RPL41
1 MRAKWRKKRM RRLKRKRRKM RQRSKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RPL41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.62
- Highest tissue expression
- 10,811 nTPM
Expression across tissuesHPA
Tissue
- ovary: 10,811 nTPM
- pancreas: 8,180 nTPM
- breast: 7,048 nTPM
- bone marrow: 6,540 nTPM
- tonsil: 6,028 nTPM
- skin: 6,017 nTPM
Single-cell type
- gastric chief cells: 10,053 nCPM
- parietal cells: 7,729 nCPM
- mucous neck cells: 6,117 nCPM
- suprabasal keratinocytes: 4,121 nCPM
- breast secretory cells: 3,279 nCPM
- basal keratinocytes: 3,167 nCPM
Immune cell
- total PBMC: 22,404 nTPM
- memory B-cell: 13,446 nTPM
- naive B-cell: 11,554 nTPM
- naive CD4 T-cell: 11,492 nTPM
- memory CD4 T-cell: 11,022 nTPM
- naive CD8 T-cell: 10,073 nTPM
Brain region
- hypothalamus: 1,618 nTPM
- thalamus: 1,489 nTPM
- spinal cord: 1,354 nTPM
- cerebral cortex: 1,308 nTPM
- choroid plexus: 1,304 nTPM
- basal ganglia: 1,262 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.6
- gnomAD pLI
- 0.18
- gnomAD missense Z
- 0.72
- DepMap mean gene effect
- -0.27
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Large ribosomal subunit protein eS32
- Ribosomal protein L41
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RPL41 as an antibody target. Whether an autoantibody or antibody against RPL41 could matter depends on whether native RPL41 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RPL41 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RPL41 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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