Seroatlas · Human Serome Atlas

RPL39L

Ribosomal protein eL39-like 2

Also known as: RL39L_HUMAN, RPL39L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EH5
Gene: RPL39L
Ensembl: ENSG00000163923
Chromosome: 3
Canonical length: 51 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

This gene encodes a protein sharing high sequence similarity with ribosomal protein L39. Although the name of this gene has been referred to as 'ribosomal protein L39' in the public databases, its official name is 'ribosomal protein L39-like'. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

51 residues, UniProt reviewed canonical sequence.

>Q96EH5|RPL39L
     1  MSSHKTFTIK RFLAKKQKQN RPIPQWIQMK PGSKIRYNSK RRHWRRTKLG L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL39L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 210 nTPM

Expression across tissuesHPA

Tissue

testis: 210 nTPM
blood vessel: 24 nTPM
pancreas: 19 nTPM
bone marrow: 18 nTPM
thymus: 15 nTPM
tonsil: 13 nTPM

Single-cell type

late primary spermatocytes: 1,482 nCPM
early spermatids: 414 nCPM
early primary spermatocytes: 412 nCPM
oocytes: 355 nCPM
late spermatids: 269 nCPM
differentiating spermatogonia: 134 nCPM

Immune cell

T-reg: 48 nTPM
memory B-cell: 33 nTPM
total PBMC: 31 nTPM
naive CD8 T-cell: 26 nTPM
memory CD4 T-cell: 25 nTPM
gdT-cell: 25 nTPM

Brain region

cerebellum: 34 nTPM
hypothalamus: 34 nTPM
white matter: 33 nTPM
cerebral cortex: 29 nTPM
thalamus: 29 nTPM
choroid plexus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.33
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of ribosome

Cellular components

cytosolic large ribosomal subunit

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL39L as an antibody target. Whether an autoantibody or antibody against RPL39L could matter depends on whether native RPL39L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL39L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL39L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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