Seroatlas · Human Serome Atlas

RPL37

Large ribosomal subunit protein eL37

Also known as: L37, RL37_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61927
Gene: RPL37
Ensembl: ENSG00000145592
Chromosome: 5
Canonical length: 97 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

97 residues, UniProt reviewed canonical sequence.

>P61927|RPL37
     1  MTKGTSSFGK RRNKTHTLCR RCGSKAYHLQ KSTCGKCGYP AKRKRKYNWS AKAKRRNTTG
    61  TGRMRHLKIV YRRFRHGFRE GTTPKPKRAA VAASSSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 1,256 nTPM

Expression across tissuesHPA

Tissue

ovary: 1,256 nTPM
thymus: 923 nTPM
breast: 706 nTPM
tongue: 671 nTPM
choroid plexus: 654 nTPM
skin: 514 nTPM

Single-cell type

extravillous trophoblasts: 7,306 nCPM
ovarian stromal cells: 6,370 nCPM
esophageal suprabasal cells: 5,772 nCPM
enteric stem cells: 5,279 nCPM
decidual stromal cells: 5,270 nCPM
gastric chief cells: 5,206 nCPM

Immune cell

total PBMC: 1,324 nTPM
memory B-cell: 1,138 nTPM
naive CD4 T-cell: 1,099 nTPM
naive B-cell: 1,034 nTPM
naive CD8 T-cell: 1,000 nTPM
memory CD4 T-cell: 960 nTPM

Brain region

spinal cord: 190 nTPM
white matter: 183 nTPM
medulla oblongata: 167 nTPM
basal ganglia: 161 nTPM
pons: 161 nTPM
thalamus: 155 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0.18
gnomAD missense Z: 0.53
DepMap mean gene effect: -1.58
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Large ribosomal subunit protein eL37/eL43
Zinc-binding ribosomal protein
Large ribosomal subunit protein eL37
Large ribosomal subunit protein eL37, conserved site
Ribosomal protein L37e

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL37 as an antibody target. Whether an autoantibody or antibody against RPL37 could matter depends on whether native RPL37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL37 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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