RPL36A

Protein identityUniProt · HPA

UniProt accession

P83881

Gene

RPL36A

Ensembl

ENSG00000241343

Chromosome

X

Canonical length

106 aa

Protein class

Metabolic proteins, Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Endoplasmic reticulum,Plasma membrane,Cytosol

OverviewNCBI Gene

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. Although this gene has been referred to as ribosomal protein L44 (RPL44), its official name is ribosomal protein L36a (RPL36A). This gene and the human gene officially named ribosomal protein L36a-like (RPL36AL) encode nearly identical proteins; however, they are distinct genes. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Naturally occurring read-through transcription occurs between this locus and the heterogeneous nuclear ribonucleoprotein H2 (H') gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

106 residues, UniProt reviewed canonical sequence.

>P83881|RPL36A
     1  MVNVPKTRRT FCKKCGKHQP HKVTQYKKGK DSLYAQGKRR YDRKQSGYGG QTKPIFRKKA
    61  KTTKKIVLRL ECVEPNCRSK RMLAIKRCKH FELGGDKKRK GQVIQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL36A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

2,024 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.89

gnomAD pLI

0.43

gnomAD missense Z

0.74

DepMap mean gene effect

-1.49

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cytoplasmic translation
• translation

Molecular functions

• RNA binding
• structural constituent of ribosome

Cellular components

• cytosol
• cytosolic large ribosomal subunit
• cytosolic ribosome
• endoplasmic reticulum
• plasma membrane
• ribosome

Protein domainsUniProt · Pfam · InterPro

• Large ribosomal subunit protein eL42
• Zinc-binding ribosomal protein
• Eukaryotic Ribosomal Large Subunit eL42
• Ribosomal protein L44

KeywordsUniProt

• Cytoplasm
• Ribonucleoprotein
• Ribosomal protein