RPL29

Protein identityUniProt · HPA

UniProt accession

P47914

Gene

RPL29

Ensembl

ENSG00000162244

Chromosome

3

Canonical length

159 aa

Protein class

Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Nucleoli,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin. Although this gene was previously reported to map to 3q29-qter, it is believed that it is located at 3p21.3-p21.2. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>P47914|RPL29
     1  MAKSKNHTTH NQSRKWHRNG IKKPRSQRYE SLKGVDPKFL RNMRFAKKHN KKGLKKMQAN
    61  NAKAMSARAE AIKALVKPKE VKPKIPKGVS RKLDRLAYIA HPKLGKRARA RIAKGLRLCR
   121  PKAKAKAKAK DQTKAQAAAP ASVPAQAPKR TQAPTKASE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.62

Highest tissue expression

2,732 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.94

gnomAD pLI

0.2

gnomAD missense Z

0.36

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cytoplasmic translation
• embryo implantation
• translation

Molecular functions

• cadherin binding
• heparin binding
• RNA binding
• structural constituent of ribosome

Cellular components

• cytoplasm
• cytosol
• cytosolic large ribosomal subunit
• cytosolic ribosome
• membrane

Protein domainsUniProt · Pfam · InterPro

• Large ribosomal subunit protein eL29
• Ribosomal L29e protein family

KeywordsUniProt

• Acetylation
• Cytoplasm
• Heparin-binding
• Methylation
• Phosphoprotein
• Repeat
• Ribonucleoprotein
• Ribosomal protein

InteractionsUniProt · HPA

Protein binding partners of RPL29 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HMGB1
• IPO5