Seroatlas · Human Serome Atlas

RPEL1

Ribulose-phosphate 3-epimerase-like protein 1

Also known as: RPEL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2QD12
Gene: RPEL1
Ensembl: ENSG00000235376
Chromosome: 10
Canonical length: 228 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable D-ribulose-phosphate 3-epimerase activity and metal ion binding activity. Predicted to be involved in carbohydrate metabolic process and pentose-phosphate shunt, non-oxidative branch. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>Q2QD12|RPEL1
     1  MASGCKIGPS ILNSDLANLG AKCLQMLDSG ADYLHLDVMD GHFVPNITFG HPVVESLRKQ
    61  LGQDPFFDMH MMVSKPEQWV KPMAVAEANQ YTFHLEATEN PGTLIKDIRE NGMKVGLAIK
   121  PGTSVEYLAP WANQIDMALV MTVEPGFGEQ KFMEDMMPKV HWLRTQFPSL DIEGDGGVGS
   181  DTVHKCAEAG ANMTVSGSAI MRSEDPRSVI NLLRNICSEA AQKRSLDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPEL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 0.1 nTPM
pituitary gland: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

retinal ganglion cells: 7.7 nCPM
rod photoreceptor cells: 2.4 nCPM
retinal bipolar cells: 2.1 nCPM
retinal amacrine cells: 1.4 nCPM
gastric progenitor cells: 1.3 nCPM
brain excitatory neurons: 0.7 nCPM

Immune cell

myeloid DC: 0.1 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 2.1 nTPM
cerebellum: 2 nTPM
white matter: 1.6 nTPM
basal ganglia: 1.4 nTPM
pons: 1.4 nTPM
amygdala: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0.01
gnomAD missense Z: 0.41
DepMap mean gene effect: 0.01
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPEL1 as an antibody target. Whether an autoantibody or antibody against RPEL1 could matter depends on whether native RPEL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPEL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPEL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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